P7769
1,2-Diacyl-sn-glycero-3-phospho-L-serine
from bovine brain, ≥97% (TLC), amorphous powder, structural phospholipid
Synonyme(s) :
3-sn-Phosphatidyl-L-serine, L-α-Phosphatidyl-L-serine, PS, Phosphatidylserine
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A propos de cet article
UNSPSC Code:
12352200
NACRES:
NA.77
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Laissez-nous vous aiderNom du produit
1,2-Diacyl-sn-glycero-3-phospho-L-serine, ≥97% (TLC), from bovine brain, amorphous powder
biological source
bovine brain
assay
≥97% (TLC)
form
amorphous powder
storage temp.
−20°C
Quality Level
Catégories apparentées
Application
1,2-Diacyl-sn-glycero-3-phospho-L-serine has been used:
- as a lipid standard in time-of-flight secondary ion mass spectrometry (ToF-SIMS) spectral fingerprints
- as a reference standard in thin layer chromatography (TLC) for quantifying lipids from astrocyte-conditioned media (ACM) treated fibroblasts
- as a component of large unilamellar vesicles for annexin A2 aggregation studies
Biochem/physiol Actions
A slowly metabolized structural phospholipid found mainly in gray matter.
1,2-Diacyl-sn-glycero-3-phospho-L-serine or phosphatidylserine (PS) is a structurally diverse acidic phospholipid having fatty acid ester at the glycerol sn positions. Bovine brain cortex based PS is a potent brain nutrient. It favors neurotransmission and may improve memory in dementia. PS is also the major membrane phospholipid associated with the nuclear membrane, myelin, endoplasmic reticulum, Golgi and mitochondria. The synthesis of PS is catalyzed by phosphatidylserine synthase 1 from L-serine and CDP-diacylglycerol in the mitochondria-associated membrane (MAM) domains of the endoplasmic reticulum. PS is externalized during phagocytosis and is dysregulated in tumors making it a potential marker for therapeutic targeting.
Features and Benefits
This compound is featured on the Phospholipase D and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Solutions exposed to room temperature will decompose about 0.5% per day.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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ApoE4 upregulates the activity of mitochondria-associated ER membranes
Tambini MD, et al.
EMBO Reports, 17(1), 27-36 (2016)
Characterization of freeze-fractured epithelial plasma membranes on nanometer scale with ToF-SIMS
Draude F, et al.
Analytical and Bioanalytical Chemistry, 407(8), 2203-2211 (2015)
Comparison of molecular species of various transphosphatidylated phosphatidylserine (PS) with bovine cortex PS by mass spectrometry
Chen S and Li KW
Chemistry and Physics of Lipids, 152(1), 46-56 (2008)
Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer
Birge RB, et al.
Cell Death and Differentiation, 23(6), 962-962 (2016)
Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells
Vance JE and Tasseva G
Biochimica et biophysica acta. General subjects, 1831(3), 543-554 (2013)
Contenu apparenté
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