P8783

Progesterone

Name: Progesterone
Brand: SIGMA

powder, BioReagent, suitable for cell culture

Synonyme(s) :

4-Pregnene-3,20-dione

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About This Item

Formule empirique (notation de Hill) :

C₂₁H₃₀O₂

Numéro CAS:

57-83-0

Poids moléculaire :

314.46

UNSPSC Code:

12352209

NACRES:

NA.77

PubChem Substance ID:

24898978

EC Number:

200-350-6

Beilstein/REAXYS Number:

1915950

MDL number:

MFCD00003658

biological source:

synthetic (organic)

form:

powder

assay:

≥99%

Nom du produit

Progesterone, powder, BioReagent, suitable for cell culture

InChI key

RJKFOVLPORLFTN-LEKSSAKUSA-N

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

SMILES string

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

biological source

synthetic (organic)

description

synthesized from materials derived from plant source

product line

BioReagent

assay

≥99%

form

powder

potency

0.1-20 ng/mL

technique(s)

cell culture | mammalian: suitable

mp

128-132 °C (lit.)

solubility

absolute ethanol: 1 mg/mL

storage temp.

room temp

Quality Level

200

Gene Information

human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208), Nr3c1(24413), Pgr(25154)

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Catégories apparentées

Biologie moléculaire et génomique fonctionnelle

Culture cellulaire et analyse

Hormones

Suppléments et réactifs pour la culture cellulaire

Biochem/physiol Actions

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Induit la maturation et l′activité secrétoire de l′endothélium utérin ; supprime l′ovulation.

Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.

Other Notes

Steroid hormone produced by the corpus luteum.

Application

Progesterone has been used:

as a growth-promoting hormone in basal medium for bovine mammary epithelial cell culture
to test its neuroprotective abilities in a well-characterized lateral cortical contusion injury (CCI) model
as an endocytosis inhibitor to study its effect on Coxsackievirus A9 infection on A549 cells

Use in cell culture applications to study sterol regulation of cell signaling and gene expression.

General description

Progesterone is a steroid hormone secreted by the ovaries.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Preparation Note

To prepare 20μg/ml stock solution, add 1ml absolute ethanol per mg progesterone, gently swirl to dissolve, add 49ml sterile medium per ml ethanol.

pictograms

GHS08

signalword

Danger

hcodes

H351,H360FD,H362

pcodes

P202 - P260 - P263 - P264 - P280 - P308 + P313

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Consulter la Bibliothèque de documents

Peroxisome proliferator-activated receptor-? activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents

A.K.G.Kadegowda, et al.

Journal of Dairy Science, 92, 276-4289 (2009)

Efficacy of progesterone following a moderate unilateral cortical contusion injury

Gilmer LK, et al.

Journal of Neurotrauma, 25(6), 593-602 (2008)

Biology of progesterone action during pregnancy recognition and maintenance of pregnancy.

Spencer T. E. and F. W. Bazer

Frontiers in Bioscience, 838, d1879-d1898 (2002)

Clinical Reproductive Medicine and Surgery, 84(7), 17-17 (2007)

Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study.

da Fonseca EB, et al.

American Journal of Obstetrics and Gynecology, 838, 419-424 (2003)

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