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A propos de cet article
Formule linéaire :
CH3(CH2)14COONa
Numéro CAS:
Poids moléculaire :
278.41
UNSPSC Code:
12352211
NACRES:
NA.25
PubChem Substance ID:
EC Number:
206-988-1
Beilstein/REAXYS Number:
3575882
MDL number:
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Laissez-nous vous aiderbiological source
plant (palm)
assay
≥98.5%
form
powder
mp
283-290 °C (lit.)
functional group
ester
lipid type
saturated FAs
shipped in
ambient
storage temp.
2-8°C
SMILES string
[Na+].CCCCCCCCCCCCCCCC([O-])=O
InChI
1S/C16H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18;/h2-15H2,1H3,(H,17,18);/q;+1/p-1
InChI key
GGXKEBACDBNFAF-UHFFFAOYSA-M
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Catégories apparentées
Application
Sodium palmitate (PA) has been used:
- to induce inflammation and thrombosis pathway in murine macrophage cell line RAW 264.7 cell line by activating reactive oxygen species (ROS) production, Janus-kinase (JNK) signalling and release of histone H3 by western blotting and cell viability by MTT assay
- to induce lipogenesis in AML12 cells and primary hepatocytes to analyse the effect of irisin on PA induced lipogenesis and related signal pathways by western blot analysis and quantitative PCR analysis
- as a component in free fatty acid mixture to induce cellular steatosis in HepG2 cell lines and determination of lipid accumulation by Oil-Red-O staining
Biochem/physiol Actions
Sodium palmitate is the sodium salt of palmitic acid, a component in hard soaps. Palmitic acid is a common saturated fatty acid and produced during fatty acid synthesis. Sodium palmitate enhances lipogenesis, cellular steatosis in various cell lines. Palmitate induces cell death in human epidermal growth factor receptor 2 (HER2)/neu-positive cells and breast cancer cell lines like MCF-7 due to enhanced fatty acid accumulation. Sodium palmitate induces lipoapoptosis in L02 and HepG2 liver cells by inducing glycogen synthase kinase-3β (GSK3β) expression.
Classe de stockage
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro
Park MJ, et al.
Cellular Signalling, 27(9), 1831-1839 (2015)
Saturated fatty acid palmitate induces extracellular release of histone H3: a possible mechanistic basis for high-fat diet-induced inflammation and thrombosis
Shrestha C, et al.
Biochemical and Biophysical Research Communications, 437(4), 573-578 (2013)
Kyong Kim et al.
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Allomyrina dichotoma larva is a nutritional-worthy future food resource and it contributes to multiple pharmacological functions. However, its antidiabetic effect and molecular mechanisms are not yet fully understood. Therefore, we investigated the hypolipidemic effect of A. dichotoma larva extract (ADLE)
José M S Fernández-Calleja et al.
Scientific reports, 9(1), 11507-11507 (2019-08-10)
Indirect calorimetry (InCa) estimates whole-body energy expenditure and total substrate oxidation based on O2 consumption and CO2 production, but does not allow for the quantification of oxidation of exogenous substrates with time. To achieve this, we incorporated 13CO2 and 12CO2
Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3 beta activation in human liver cells
Cao J, et al.
Digestive Diseases and Sciences, 59(2), 346-357 (2014)
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