PZ0143
PF-4708671
≥98% (HPLC)
Synonyme(s) :
2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole
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A propos de cet article
Formule empirique (notation de Hill) :
C19H21F3N6
Numéro CAS:
Poids moléculaire :
390.41
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Service technique
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assay
≥98% (HPLC)
form
powder
color
off-white
solubility
DMSO: ≥20 mg/mL
storage temp.
room temp
SMILES string
CCC(C=NC=N1)=C1N2CCN(CC3=NC4=C(C=CC(C(F)(F)F)=C4)N3)CC2
InChI
1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26)
InChI key
FBLPQCAQRNSVHB-UHFFFAOYSA-N
Gene Information
human ... RPS6KB1(6198)
mouse ... Rps6kb1(72508)
rat ... Rps6kb1(83840)
Biochem/physiol Actions
PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor.
PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor. PF-4708671 inhibits S6K1 with a Ki of 20 nM and IC50 of 160 nM, while having no effect on the closely related RSK and MSK kinases.
Features and Benefits
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Classe de stockage
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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