S3132
Seleno-L-methionine
≥98% (TLC), powder, IgE expression inhibitor
Synonyme(s) :
(S)-2-Amino-4-(methylseleno)butyric acid
Se connecter pour consulter les tarifs organisationnels et contractuels.
Sélectionner une taille de conditionnement
A propos de cet article
Formule linéaire :
CH3SeCH2CH2CH(NH2)CO2H
Numéro CAS:
Poids moléculaire :
196.11
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
Service technique
Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.
Laissez-nous vous aiderService technique
Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.
Laissez-nous vous aiderNom du produit
Seleno-L-methionine, ≥98% (TLC), powder
SMILES string
C[Se]CC[C@H](N)C(O)=O
InChI
1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChI key
RJFAYQIBOAGBLC-BYPYZUCNSA-N
assay
≥98% (TLC)
form
powder
color
white to off-white
solubility
H2O: 50 mg/mL
storage temp.
−20°C
Quality Level
Vous recherchez des produits similaires ? Visite Guide de comparaison des produits
Catégories apparentées
Application
Seleno-L-methionine has been used:
- in toxicity studies in Japanese Medaka embryos
- to study its effects on selenium status indicators in pregnant long-tailed macaques (Macaca Fascicularis)
- to label proteins for single wavelength anomalous dispersion (SAD) phasing
Seleno-L-methionine has been used:
- as a nonchemical stressor to treat Japanese Medaka fish embryos
- to label proteins for Single wavelength Anomalous Dispersion (SAD) phasing
- to study the distribution and inhibition effects of seleno-L-methionine on 4T1 mouse mammary carcinoma
Biochem/physiol Actions
Seleno-L-Methionine (SeMet) is capable of repressing atopic dermatitis (AD)-like skin lesions. It can also prevent the expression of total immunoglobulin E (IgE) and interleukin 4 (IL-4). It can cause ecotoxicity as it is absorbed by fish through diet.
Seleno-L-methionine displays antioxidant activity and has been shown to increase the activity of glutathione peroxidase in endothelial cells. Glutathione peroxidase protects cells from oxidative damage, such as DNA strand breaks, mutations and interference with protein tyrosine-based signaling and other protein functions due to formation of 3-nitrotyrosine, caused by excessive peroxynitrite. Seleno-L-methionine administration to cancer cell lines (MCF-7/S breast carcinoma, DU-145 prostate cancer cells and UACC-375 melanoma) results in apoptotic cell death and aberrant mitosis. These human tumor cell lines exhibited dose-dependent growth inhibition by selenomethionine in the micromolar range (45 to 130μM), while growth inhibition of normal fibroblasts required 1mM selenomethionine.
General description
Seleno-L-Methionine (SeMet), an organic form of selenium is found in Cupriavidus metallidurans.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
Classe de stockage
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
250.3 - 346.3 °F
flash_point_c
121.3 - 174.6 °C
Faites votre choix parmi les versions les plus récentes :
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Arka Chakraborty et al.
Nucleic acids research, 45(2), 951-967 (2016-12-03)
The mitochondrial genome (mtDNA) is assembled into nucleo-protein structures termed nucleoids and maintained differently compared to nuclear DNA, the involved molecular basis remaining poorly understood. In yeast (Saccharomyces cerevisiae), mtDNA is a ∼80 kbp linear molecule and Abf2p, a double
H Sies et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 53(3-4), 228-232 (1998-06-10)
Cellular defense against excessive peroxynitrite generation is required to protect against DNA strand-breaks and mutations and against interference with protein tyrosine-based signaling and other protein functions due to formation of 3-nitrotyrosine. We recently demonstrated a role of selenium-containing enzymes catalyzing
Seleno-L-methionine is the predominant organic form of selenium in Cupriavidus metallidurans CH34 exposed to selenite or selenate
Avoscan L, et al.
Applied and Environmental Microbiology, 72(9), 6414-6416 (2006)
A protocol to retain weakly interacting protein complexes for structural studies using an appropriate linker
Chichili VPR, et al.
Protocol Exchange (2013)
Distribution and inhibition effect of Seleno-L-Methionine on 4T1 mouse mammary carcinoma.
Song H
International Journal of Physiology, Pathophysiology and Pharmacology, 7(2), 76-86 (2015)
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique