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Merck

S6508

Sodium orthovanadate

synthetic (organic), ≥90% (titration), protein tyrosine phosphatase inhibitor, crystalline powder

Synonyme(s) :

Trisodium vanadate

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About This Item

Formule linéaire :
Na3VO4
Numéro CAS:
13721-39-6
Poids moléculaire :
183.91
NACRES:
NA.77
PubChem Substance ID:
24899708
UNSPSC Code:
12352200
EC Number:
237-287-9
MDL number:
MFCD00003511

Nom du produit

Sodium orthovanadate, ≥90% (titration)

InChI key

IHIXIJGXTJIKRB-UHFFFAOYSA-N

InChI

1S/3Na.4O.V/q3*+1;;3*-1;

SMILES string

[Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O

biological source

synthetic (organic)

assay

≥90% (titration)

form

crystalline powder

reaction suitability

reagent type: catalyst
core: vanadium

color

white to off-white

mp

850-866 °C (lit.)

solubility

H2O: soluble

Quality Level

200

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Catégories apparentées

Application

Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase.26 It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.27

Biochem/physiol Actions

Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release from endocrine cells and blocks IP3 binding to its receptor in brain tissue.
Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.24 In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.25

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Classe de stockage

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
0000268527
0000469370
0000469370
0000268527
0000347365

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

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  1. How do I prepare solutions of Product S6508, Sodium Orthovanadate?

    Solutions of Product S6508, Sodium Orthovanadate, prepared as 1 mM in water (or higher if desired) and adjusted down to pH 10 can be aliquotted in plastic tubes and stored at -20°C. To ensure the presence of monomers, solutions should be heated to boiling until translucent and pH readjusted to 10. View the product information sheet (under Documents, above), which has more details.

  2. How do I store solutions of Product S6508, Sodium Orthovanadate?

    Solutions of Product S6508, Sodium Orthovanadate, prepared as 1 mM in water (or higher if desired) and adjusted down to pH 10 can be aliquotted in plastic tubes and stored at -20°C. To ensure the presence of monomers, solutions should be heated to boiling until translucent and pH readjusted to 10. View the product information sheet (under Documents, above), which has more details.

  3. What is the amount of S6508, Sodium orthovanadate, needed for inhibition?

    For ATPase, a 0.5-1 μM concentration of sodium orthovanadate inhibited 50% of the activity. Please see the product information sheet (under Documents, above) which provides references on several other enzymes.

  4. Which enzymes does S6508 inhibit?

    Sodium orthovanadate is an inhibitor of ATPase, alkaline phosphatase and tyrosine phosphatase.

  5. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  6. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

C Cerella et al.
Cell death & disease, 6, e1782-e1782 (2015-06-13)
Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na(+)/K(+))-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extracted from the plant Calotropis procera, which is
Christopher N J Young et al.
Autophagy, 11(1), 113-130 (2015-02-24)
P2RX7 is an ATP-gated ion channel, which can also exhibit an open state with a considerably wider permeation. However, the functional significance of the movement of molecules through the large pore (LP) and the intracellular signaling events involved are not
Serena Orlando et al.
Nucleic acids research, 43(14), 6860-6873 (2015-06-15)
Transcriptional repressor complexes containing p130 and E2F4 regulate the expression of genes involved in DNA replication. During the G1 phase of the cell cycle, sequential phosphorylation of p130 by cyclin-dependent kinases (Cdks) disrupts these complexes allowing gene expression. The Cdk
Roser Buscà et al.
BMC evolutionary biology, 15, 179-179 (2015-09-04)
The Ras/Raf/MEK/ERK signaling pathway is involved in essential cell processes and it is abnormally activated in ~30 % of cancers and cognitive disorders. Two ERK isoforms have been described, ERK1 and ERK2; ERK2 being regarded by many as essential due
Erika López-Arribillaga et al.
Development (Cambridge, England), 142(1), 41-50 (2014-12-07)
Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation of the transit-amplifying cells into post-mitotic
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