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Merck

S9012

Sulforhodamine B sodium salt

Powder

Synonyme(s) :

Acid red 52; Acid Rhodamine B

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A propos de cet article

Formule empirique (notation de Hill) :
C27H29N2NaO7S2
Numéro CAS:
3520-42-1
Poids moléculaire :
580.65
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
24899824
EC Number:
222-529-8
MDL number:
MFCD00010180
Colour Index Number:
45100
Beilstein/REAXYS Number:
3886008

Principaux documents

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Nom du produit

Sulforhodamine B sodium salt, Technical grade

InChI

1S/C27H30N2O7S2.Na/c1-5-28(6-2)18-9-12-21-24(15-18)36-25-16-19(29(7-3)8-4)10-13-22(25)27(21)23-14-11-20(37(30,31)32)17-26(23)38(33,34)35;/h9-17H,5-8H2,1-4H3,(H-,30,31,32,33,34,35);/q;+1/p-1

InChI key

SXQCTESRRZBPHJ-UHFFFAOYSA-M

SMILES string

[Na+].CCN(CC)c1ccc2c(OC3=CC(\C=CC3=C2c4ccc(cc4S([O-])(=O)=O)S([O-])(=O)=O)=[N+](\CC)CC)c1

form

powder

composition

Dye content, ~75%

εmax

≥85000 at 554-560 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

200

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Catégories apparentées

Application

Sulforhodamine B (SRB) is known for use in SRB assay for the determination of in vitro cytotoxicity through staining and the observation of live cells, proliferation and drug screening.

It has been used in the SRB assay to evaluate the effect of mouthwashes on protein content in primary cultures of human fibroblasts.

It is also suitable as a microscopic tracer for the assessment of blood-brain barrier integrity by post mortem inspection of frozen sections. SRB is useful as a caries detector dye with subsequent inspection of histological material.

General description

Sulforhodamine B (also known as SRB, kiton rhodamine B, lissamine rhodamine B, or sulphorhodamine B) is a bright-pink anionic, aminoxanthene dye carrying two sulfonate substituents.

Classe de stockage

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
SHBT3820
SHBR6190
SHBR3284
SHBL1004
MKCF2845

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Samantha N Andrews et al.
Pharmaceutical research, 30(4), 1099-1109 (2012-12-01)
Most methods to increase transdermal drug delivery focus on increasing stratum corneum permeability, without addressing the need to increase permeability of viable epidermis. Here, we assess the hypothesis that viable epidermis offers a significant permeability barrier that becomes rate limiting
Xinyuan Chen et al.
Journal of controlled release : official journal of the Controlled Release Society, 159(1), 43-51 (2012-01-21)
Full-surface laser ablation has been shown to efficiently disrupt stratum corneum and facilitate transcutaneous drug delivery, but it is frequently associated with skin damage that hampers its clinic use. We show here that a safer ablative fractional laser (AFL) can
Evangelia Sereti et al.
Biomedicines, 9(1) (2021-01-21)
Sigma (σ) receptors have attracted great interest since they are implicated in various cellular functions and biological processes and diseases, including various types of cancer. The receptor family consists of two subtypes: sigma-1 (σ1) and sigma-2 (σ2). Both σ receptor
Gang Chen et al.
Cancer research, 74(16), 4536-4548 (2014-06-21)
Cancer stem cells, capable of self-renewal and multipotent differentiation, influence tumor behavior through a complex balance of symmetric and asymmetric cell divisions. Mechanisms regulating the dynamics of stem cells and their progeny in human cancer are poorly understood. In Drosophila
M Maltz et al.
Journal of dentistry, 40(9), 776-782 (2012-06-06)
The aim of this study was to compare microbiological infection after conventional carious dentine removal with incomplete carious dentine removal and sealing. Eighty-seven patients (12-50 years of age) under treatment at the Dental Clinics of the Federal University of Rio
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