Anti-CAV1 (Ab-14) antibody produced in rabbit

Caveolin-1 (CAV1) is a multifunctional scaffolding protein , that has three exons. It is located on human chromosome 7q31.

The scaffolding protein encoded by Caveolin-1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.

Peptide sequence around aa. 12-16 (H-L-Y-T-V), according to the protein CAV1.

Caveolin-1 is expected to play a major role in the growth and evolution of cancer. It participates in glucose metabolism. It may also participate in angiogenesis. Cav-1 helps to control the expression of glucose transporters.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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