SAB4500896
Anti-COPZ1 antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
ζ1-COP, CGI-120, COPZ, coatomer protein complex, subunit ζ 1
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A propos de cet article
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
5
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Laissez-nous vous aiderQuality Level
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 20 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... COPZ1(22818)
General description
Anti-COPZ1 Antibody detects endogenous levels of total COPZ1 protein.
COPZ1 (coatomer protein complex ζ1) codes for a subunit of coatomer protein complex 1 (COPI). It is a secretory vesicle coat protein. It is located on human chromosome 12q13.
Immunogen
The antiserum was produced against synthesized peptide derived from human COPZ1.
Immunogen Range: 11-60
Immunogen Range: 11-60
Application
Anti-COPZ1, N-Terminal antibody has been used in immunohistochemistry , immunofluorescence and western blotting.
Biochem/physiol Actions
COPZ1 (coatomer protein complex ζ1) participates in intracellular traffic and autophagy, and endosome maturation. Suppression of COPZ1 promotes apoptosis in proliferating and nondividing tumor cells.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Classe de stockage
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Targeting COPZ1 non-oncogene addiction counteracts the viability of thyroid tumor cells
Anania MC, et al.
Cancer Letters, 410, 201-211 (2017)
Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathway
Narkis G, et al.
American Journal of Human Genetics, 81, 589-595 (2007)
Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ? 2 renders tumor cells dependent on its paralogous gene COPZ1
Shtutman M, et al.
Proceedings of the National Academy of Sciences of the USA, 108, 12449-12454 (2011)
Maria Chiara Anania et al.
Cancer letters, 410, 201-211 (2017-09-28)
Thyroid carcinoma is generally associated with good prognosis, but no effective treatments are currently available for aggressive forms not cured by standard therapy. To find novel therapeutic targets for this tumor type, we had previously performed a siRNA-based functional screening
Eileen Sun et al.
Journal of virology, 87(5), 2673-2685 (2012-12-21)
As an obligate pathogen, influenza virus requires host cell factors and compartments to mediate productive infection and to produce infectious progeny virus. Recently, several small interfering RNA (siRNA) knockdown screens revealed influenza virus host dependency proteins, all of which identified
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