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Merck

SML0407

ML141

≥98% (HPLC)

Synonyme(s) :

4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide

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About This Item

Formule empirique (notation de Hill) :
C22H21N3O3S
Numéro CAS:
71203-35-5
Poids moléculaire :
407.49
UNSPSC Code:
12352200
PubChem Substance ID:
329825402
NACRES:
NA.77
MDL number:
MFCD05987165

Nom du produit

ML 141, ≥98% (HPLC)

SMILES string

NS(C1=CC=C(C=C1)N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)(=O)=O

InChI

1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27)

InChI key

QBNZBMVRFYREHK-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (warmed, clear solution)

storage temp.

2-8°C

Quality Level

100

Catégories apparentées

Application

ML 141 has been used:
  • to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells
  • as inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nuclei
  • as actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria
  • as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells

Biochem/physiol Actions

ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42.
ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42. The IC50 for inhibition of enzymatic activity is 200 nM, with no activity against Rho family members Rac, Ras or Rab. Cdc42 has been implicated in the regulation of actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. This complex mediates the polymerization of actin into branched networks and regulates important functions including cell adhesion, cytoskeletal arrangement, phagocytosis and host-pathogen interactions, motility, migration, and membrane protein trafficking.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000145085
0000105828
0000076361
0000067576

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Consulter la Bibliothèque de documents

Local arrangement of fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells
Roman W, et al.
Developmental Cell, 46(1), 102-111 (2018)
Multiple routes of endocytic internalization of PDGFR beta contribute to PDGF-induced STAT3 signaling
Jastrzkebski K, et al.
Journal of Cell Science, 130(3), 577-589 (2017)
Intracellular periodontal pathogen exploits recycling pathway to exit from infected cells
Takeuchi H, et al.
Cellular Microbiology, 18(7), 928-948 (2016)
Brennan D Gerlach et al.
Cell death and differentiation, 27(2), 525-539 (2019-06-22)
Inflammation-resolution is a protective response that is mediated by specialized pro-resolving mediators (SPMs). The clearance of dead cells or efferocytosis is a critical cellular program of inflammation-resolution. Impaired efferocytosis can lead to tissue damage in prevalent human diseases, like atherosclerosis.
Myosin VI-dependent actin cages encapsulate parkin-positive damaged mitochondria
Kruppa AJ, et al.
Developmental Cell, 44(4), 484-499 (2018)
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