SML0949
4μ8C
≥98% (HPLC), IRE1 Inhibitor, powder
Synonyme(s) :
7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde
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About This Item
Formule empirique (notation de Hill) :
C11H8O4
Numéro CAS:
Poids moléculaire :
204.18
UNSPSC Code:
12352200
NACRES:
NA.77
Nom du produit
4μ8C, ≥98% (HPLC)
SMILES string
O1c2c(ccc(c2C=O)O)C(=CC1=O)C
InChI
1S/C11H8O4/c1-6-4-10(14)15-11-7(6)2-3-9(13)8(11)5-12/h2-5,13H,1H3
InChI key
RTHHSXOVIJWFQP-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
−20°C
Quality Level
Catégories apparentées
Biochem/physiol Actions
4μ8C is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. 4μ8C inhibits regulated IRE1-dependent degradation (RIDD) and unconventional spicing of XBP1 mRNA in response to endopasmic reticulum (ER) stress, but has no affect on the kinase activity of IRE1.
4μ8C is a potent inhibitor of the ER transmembrane protein IRE1.
4μ8C is a salicylaldehyde derivative and its inhibitory action targets the K907 lysine residue in RNase (ribonuclease) domain and affects IRE1α (endoplasmic reticulum to nucleus signaling 1) RNase activity. In vitro analysis proved that 4μ8C was able to inhibit the release of insulin at high glucose levels.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Su Xian et al.
EMBO reports, 22(12), e52509-e52509 (2021-10-27)
Aneuploidy is a chromosomal abnormality associated with poor prognosis in many cancer types. Here, we tested the hypothesis that the unfolded protein response (UPR) mechanistically links aneuploidy and local immune dysregulation. Using a single somatic copy number alteration (SCNA) score
Jirka Peschek et al.
EMBO reports, 16(12), 1688-1698 (2015-10-21)
The kinase/endonuclease IRE1 is the most conserved signal transducer of the unfolded protein response (UPR), an intracellular signaling network that monitors and regulates the protein folding capacity of the endoplasmic reticulum (ER). Upon sensing protein folding perturbations in the ER
Targeting the IRE1α?XBP1 branch of the unfolded protein response in human diseases.
Jiang D, et al.
Seminars in Cancer Biology, 33, 48-56 (2015)
Mst Mamuna Sharmin et al.
Journal of dairy science, 104(11), 12094-12104 (2021-08-09)
Insulin-like growth factor-1 (IGF-1) plays a key role in proliferation and galactopoiesis in mammary epithelial cells (MEC), but its definitive functions on endoplasmic reticulum (ER) during protein synthesis remain unknown. The present study aimed to elucidate the effects of IGF-1
4μ8C inhibits insulin secretion independent of IRE1α RNase activity.
Sato H, et al.
Cell Structure and Function, 42(1), 61-70 (2017)
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