SML1639
BRD3308
≥98% (HPLC)
Synonyme(s) :
4-Acetamido-N-(2-amino-4-fluorophenyl)benzamide
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A propos de cet article
Formule empirique (notation de Hill) :
C15H14FN3O2
Numéro CAS:
Poids moléculaire :
287.29
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Laissez-nous vous aiderQuality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC(NC1=CC=C(C(NC2=CC=C(F)C=C2N)=O)C=C1)=O
InChI
1S/C15H14FN3O2/c1-9(20)18-12-5-2-10(3-6-12)15(21)19-14-7-4-11(16)8-13(14)17/h2-8H,17H2,1H3,(H,18,20)(H,19,21)
InChI key
RRJDFENBXIEAPD-UHFFFAOYSA-N
Biochem/physiol Actions
BRD3308 is a highly selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 value of 65 nM for HDAC3 vs. IC50 values of 1.08 μM and 1.15 μM for HDAC1 and HDAC2, respectively. BRD3308 protected pancreatic β cells, suppressing inflammatory cytokine-induced apoptosis and increasing insulin release without the toxicity associated with HDAC1 and HDAC2 inhibitors. In a rat model of type 2 diabetes, BRD3308 reduced hyperglycemia and increased insulin secretion without affecting weight gain. In another study, BRD3308 was found to activate HIV-1 transcription, disrupting HIV-1 latency.
BRD3308 is a highly selective inhibitor of histone deacetylase 3 (HDAC3).
BRD3308 promotes outgrowth of HIV-1 (human immunodeficiency virus 1) from inactive infected patient cells. It helps to increase β-cell proliferation.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes.
Dirice E, et al.
The Journal of Biological Chemistry, 292(43), 17598-17608 (2017)
International Review of Cell and Molecular Biology, 300-300 (2017)
S V Demyanenko et al.
Brain research bulletin, 162, 151-165 (2020-06-28)
Epigenetic processes play important roles in brain responses to ischemic injury. We studied effects of photothrombotic stroke (PTS, a model of ischemic stroke) on the intracellular level and cellular localization of histone deacetylases HDAC3, HDAC4 and HDAC6 in the rat