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SML1661

Bafilomycin A1

Name: Bafilomycin A1
Brand: SIGMA

from Streptomyces griseus, ≥90% (HPLC), DMSO solution, V-ATPase inhibitor

Synonyme(s) :

BafA1

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A propos de cet article

Formule empirique (notation de Hill) :

C₃₅H₅₈O₉

Numéro CAS:

88899-55-2

Poids moléculaire :

622.83

UNSPSC Code:

12352200

NACRES:

NA.77

Form:

DMSO solution

Quality level:

200

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Propriétés

Nom du produit

Bafilomycin A1 Ready Made Solution, 0.16 mM in DMSO, from Streptomyces griseus

biological source

Streptomyces griseus

Quality Level

200

form

DMSO solution

concentration

0.16 mM in DMSO

shipped in

dry ice

storage temp.

−20°C

SMILES string

O1[C@@H]([C@H]([C@@H](C[C@]1(O)[C@H]([C@H](O)[C@@H]([C@H]2OC(=O)\C(=C\C(=C\[C@H]([C@H]([C@H](C\C(=C\C=C\[C@@H]2OC)\C)C)O)C)\C)\OC)C)C)O)C)C(C)C

InChI

1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1

InChI key

XDHNQDDQEHDUTM-JQWOJBOSSA-N

Description

General description

Bafilomycin A1, a macrolide antibiotic, belongs to the pleomacrolides family. It acts as a potent and selective inhibitor of vacuolar-type H⁺-ATPase. BafA1 can inhibit the viability of MG63 osteosarcoma cells. It can also stimulate mitochondrial dysfunction. BafA1 inhibits the proliferation of different types of cancer cells.

Application

Bafilomycin A1 has been used:

as an endosome acidification inhibitor to study the importance of endosome acidification in the extracellular vesicle uptake and cytosolic release of stably expressing NanoLuc luciferase-tagged Hsp70 (NLuc-Hsp70) in HeLa cells
as a vacuolar-type H⁺-ATPase (V-ATPase) inhibitor to study its effects on autophagic turnover of light chain 3 β (LC3-II) in mice
as an autophagy inhibitor to study its effects on primary rat liver sinusoidal endothelial cells (LSECs) defenestration

Biochem/physiol Actions

Bafilomycin A1 inhibits autophagy. It may exhibit anti-tumorigenic, anti-parasitic, and anti-neurodegenerative effects. Bafilomycin A1, found in lysosomes and endosomes prevents the acidification of these cell organelles. It also participates in blocking autophagosome-lysosome fusion and autolysosome acidification, steps necessary for maintaining the autophagic flux and cellular homeostasis.

Bafilomycin A1 is a macrolide antibiotic.

Bafilomycin A1 is a macrolide antibiotic. Bafilomycin A1 acts as a potent and selective inhibitor of vacuolar-type H⁺-ATPase.

Other Notes

Bafilomycin A1 solution is provided in concentration of 0.16 mM. Typical concentrations for use in cell culture are 50-100 nM.

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Classe de stockage

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

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Certificats d'analyse (COA)

Lot/Batch Number

0000529702

0000503528

0000505934

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Consulter la Bibliothèque de documents

Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways

Yan Y, et al.

Scientific Reports (2016)

Bafilomycin A1 inhibits autophagy and induces apoptosis in MG63 osteosarcoma cells

Xie Z, et al.

Molecular medicine reports (2014)

Molecular basis of V-ATPase inhibition by bafilomycin A1

Wang R, et al.

Nature Communications (2021)

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