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Merck

SRE0027

Héparine sodium salt from porcine intestinal mucosa

Synonyme(s) :

Heparin sodium salt from porcine intestinal mucosa

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A propos de cet article

Numéro CAS:
9041-08-1
UNSPSC Code:
12352201
NACRES:
NA.21
MDL number:
MFCD00081689

Principaux documents

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biological source

Porcine (mucosa)

Quality Level

400

form

powder

color

white to off-white

solubility

water: 50 mg/mL (colorless to faint yellow)

application(s)

diagnostic assay manufacturing

SMILES string

[Na+].[S](=O)(=O)(NC1C(OC(C(C1O[S](=O)(=O)O)OC4OC(C(C(C4O[S](=O)(=O)O)O)O)C(=O)O)CO)OC2C(OC(C(C2O)O[S](=O)(=O)O)OC3C(OC(C(C3O)NC(=O)C)O)CO[S](=O)(=O)O)C(=O)O)O

InChI

1S/C26H42N2O37S5.Na/c1-4(30)27-7-9(31)13(6(56-23(7)39)3-55-67(43,44)45)58-26-19(65-70(52,53)54)12(34)16(20(62-26)22(37)38)60-24-8(28-66(40,41)42)15(63-68(46,47)48)14(5(2-29)57-24)59-25-18(64-69(49,50)51)11(33)10(32)17(61-25)21(35)36;/h5-20,23-26,28-29,31-

InChI key

JRTRSJGZMRQDHI-UHFFFAOYSA-N

Catégories apparentées

General description

Heparin is a polymer classified as a mucopolysaccharide or a glycosaminoglycan. It is biosynthesized and stored in mast cells of various mammalian tissues, particularly liver, lung, and mucosa. Commercial heparin is chiefly isolated from beef lung or pork intestinal mucosa.

Application

  • Heparin is traditionally used as an anticoagulant. It binds to antithrombin III, a naturally occurring plasma protease inhibitor, accelerating significantly the rate at which antithrombin III (AT-III) inhibits coagulation proteases (Factor Xa and thrombin).
  • In addition, heparin is shown to stabilize tryptase as an enzymatically active tetramer.

Features and Benefits

Features:
  1. Qualified Raw Materials: Products that meet the stringent requirements of the Elevated Assurance Program, ensuring compliance with regulatory standards.
  2. Comprehensive Documentation: Includes essential documents such as certificates, impurity profiles, and declarations to support audits and risk assessments.
  3. M-Clarity™ Quality Attributes: Products are classified within the MQ300 quality segment or higher, demonstrating superior quality assurance. M-Clarity™ Program
  4. Confirmed Process Controls: Established processes that ensure consistency and reliability in manufacturing.
  5. Enhanced Change Notification: Timely updates on any changes to product specifications or processes, ensuring transparency and compliance.
  6. Freely Available Dossiers: Access to robust, ready-to-present product dossiers that include:
    1. Site quality assessment
    2. ISO 9001 certificate
    3. Detailed product specifications
    4. Relevant declarations/statements (e.g., animal origin content, BSE/TSE, nitrosamine)
Benefits:
  1. Regulatory Compliance: Helps you meet compliance standards effectively, reducing the risk of regulatory issues.
  2. Audit Readiness: Instills confidence during audits with comprehensive documentation and confirmed process controls, demonstrating your commitment to high-quality products.
  3. Operational Transparency: Supports supply chain transparency, allowing you to track and verify the quality of raw materials.
  4. Enhanced Support: Provides exceptional quality-related information and tailored assistance to meet your specific needs.
  5. Risk Mitigation: Facilitates thorough risk assessments with detailed documentation, helping you manage potential compliance challenges.
  6. Informed Decision-Making: Access to clear and comprehensive product information enables better decision-making and enhances operational efficiency.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Legal Information

M-CLARITY is a trademark of Merck KGaA, Darmstadt, Germany

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Certificats d'analyse (COA)

Lot/Batch Number
0000511994
0000537478
0000408158
0000528382
0000537478

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Consulter la Bibliothèque de documents

Dalia Abdelrahim Alzebdeh et al.
Journal of cellular biochemistry, 118(9), 3003-3015 (2017-03-03)
In vitro assembly of functional liver tissue is a prerequisite for the transplantation of tissue-engineered livers. There is an increasing demand for in vitro models that replicate complex events occurring in the liver. However, tissue engineering of implantable liver systems
Jae Myoung Suh et al.
Nature, 513(7518), 436-439 (2014-07-22)
Fibroblast growth factor 1 (FGF1) is an autocrine/paracrine regulator whose binding to heparan sulphate proteoglycans effectively precludes its circulation. Although FGF1 is known as a mitogenic factor, FGF1 knockout mice develop insulin resistance when stressed by a high-fat diet, suggesting a

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