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Merck

WH0004292M2

Monoclonal Anti-MLH1 antibody produced in mouse

clone M1, purified immunoglobulin, buffered aqueous solution

Synonyme(s) :

Anti-COCA2, Anti-FCC2, Anti-HNPCC, Anti-HNPCC2, Anti-MGC5172, Anti-hMLH1, Anti-mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)

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A propos de cet article

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00282360
Conjugate:
unconjugated
Clone:
M1, monoclonal
Application:
ELISA (i), IF, IHC (p), PLA, WB
Citations:
11

Principaux documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

M1, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: suitable, indirect immunofluorescence: suitable, proximity ligation assay: suitable, western blot: 1-5 μg/mL

isotype

IgGκ

GenBank accession no.

BC006850

UniProt accession no.

P40692

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... MLH1(4292)

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Catégories apparentées

General description

MutL homolog 1 (MLH1) is a nucleoprotein and a major component of mismatch repair system. The MLH1 gene is localized on human chromosome 3p21 and is made up of 19 exons. The protein has a molecular weight of 80kDa. MLH1 promotes colorectal carcinogenesis.

Immunogen

MLH1 (AAH06850, 1 a.a. ~ 756 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC

Application

Monoclonal Anti-MLH1 antibody produced in mouse has been used for immunocytochemistry and Western blotting.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Classe de stockage

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificats d'analyse (COA)

Lot/Batch Number
J9101-M1
06125-M1
06097-M1

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Consulter la Bibliothèque de documents

Ha Thi Nguyen et al.
Molecular human reproduction, 20(10), 981-989 (2014-08-02)
It is well known that human embryonic stem cells (hESCs) frequently acquire recurrent chromosomal abnormalities, very reminiscent of those found in cancerous cells. Given the parallels between cancer and stem cell biology, we set out to investigate the occurrence of
Loss of MutL Disrupts CHK2-Dependent Cell-Cycle Control through CDK4/6 to Promote Intrinsic Endocrine Therapy Resistance in Primary Breast Cancer
Svasti H
Cancer Discovery (2017)
Lewis Au et al.
Cancer cell, 39(11), 1497-1518 (2021-10-30)
ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma (ccRCC) aiming to understand the mechanism underpinning therapeutic response. Genomic analyses show no correlation between
DNA mismatch repair gene MLH1 induces apoptosis in prostate cancer cells.
Fukuhara S
Oncotarget (2014)
Human embryonic stem cells show low-grade microsatellite instability
Ha Thi
Molecular Human Reproduction (2014)
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