X1126

Xylazine

Name: Xylazine
Brand: SIGMA

≥99%, Alpha-2 adrenergic agonist

Synonyme(s) :

2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine

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About This Item

Formule empirique (notation de Hill) :

C₁₂H₁₆N₂S

Numéro CAS:

7361-61-7

Poids moléculaire :

220.33

NACRES:

NA.77

PubChem Substance ID:

24902128

UNSPSC Code:

12352200

EC Number:

230-902-1

MDL number:

MFCD00057908

Nom du produit

Xylazine, ≥99%

InChI key

BPICBUSOMSTKRF-UHFFFAOYSA-N

InChI

1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)

SMILES string

Cc1cccc(C)c1NC2=NCCCS2

assay

≥99%

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

storage temp.

−20°C

Quality Level

200

Application

Xylazine has been used to anaesthetise experimental animals.

Biochem/physiol Actions

α₂-adrenoceptor agonist, sedative, muscle relaxant.

Xylazine when used along with ketamine is considered to be a potent and safe anaesthetic in experimental animal. It is known to elevate the hepatic release of glucose, which aggravates to hyperglycemia.

General description

Xylazine is soluble in methanol (50 mg/ml), yielding a clear, colorless solution. It is also soluble in dilute HCl acid and in chloroform. Xylazine is practically insoluble in water and in alkali solutions.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Acute reversible cataract induced by xylazine and by ketamine-xylazine anesthesia in rats and mice

Calderone L, et al.

Experimental Eye Research, 42(4), 331-337 (1986)

MIND model for triple-negative breast cancer in syngeneic mice for quick and sequential progression analysis of lung metastasis

Ghosh A, et al.

PLoS ONE, 13(5), e0198143-e0198143 (2018)

Effect of xylazine on plasma glucose, glucagon and insulin concentrations in sheep

Brockman, RP

Research in Veterinary Science, 30(3), 383-384 (1981)

Lactobacillus casei addition to a repletion diet-induced early normalisation of cytokine profils during a pneumococcal infection in malnourished mice

Salva S, et al.

Food and agricultural immunology, 19(3), 195-211 (2008)

Mechanical ventilation causes airway distension with proinflammatory sequelae in mice.

Hannah T Nickles et al.

American journal of physiology. Lung cellular and molecular physiology, 307(1), L27-L37 (2014-05-13)

The pathogenesis of ventilator-induced lung injury has predominantly been attributed to overdistension or mechanical opening and collapse of alveoli, whereas mechanical strain on the airways is rarely taken into consideration. Here, we hypothesized that mechanical ventilation may cause significant airway

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Product Information Sheet - X1126

Product Information Sheet

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