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Merck

X1629

Anti-XPG (C-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-COFS3, Anti-ERCC5, Anti-ERCM2, Anti-UVDR, Anti-XPGC

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A propos de cet article

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
indirect immunofluorescence
western blot
Species reactivity:
human
Citations:
6
Technique(s):
indirect immunofluorescence: 2-4 μg/mL using HEK-293T cells expressing recombinant XPG fusion protein, fixed with paraformaldehyde-Triton
western blot: 1-2 μg/mL using whole cell lysates of COS7 cells expressing recombinant XPG fusion protein
Uniprot accession no.:
P28715

Principaux documents

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Nom du produit

Anti-XPG (C-terminal) antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

concentration

~1 mg/mL

technique(s)

indirect immunofluorescence: 2-4 μg/mL using HEK-293T cells expressing recombinant XPG fusion protein, fixed with paraformaldehyde-Triton
western blot: 1-2 μg/mL using whole cell lysates of COS7 cells expressing recombinant XPG fusion protein

UniProt accession no.

P28715

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ERCC5(2073)

Application

Anti-XPG (C-terminal) antibody produced in rabbit has been used in:
  • staining cells for xeroderma pigmentosum group G (XPG) detection
  • immunoblotting
  • immunofluorescence

Biochem/physiol Actions

Xeroderma pigmentosum group G (XPG) helps to maintain genomic stability. It also participates in RNA transcription by interacting with TFIIH, RNA polymerase II and Gadd45a. XPG also participates in nucleotide excision repair (NER) pathway. Mutations in the XPG gene cause the Cockayne syndrome which is characterized by severe growth defects, mental retardation and cachexia.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Anti-XPG (C-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to amino acids 1120-1137 of human XPG, conjugated to KLH via an N-terminal added cysteine residue. Xeroderma pigmentosum group G (XPG) is a DNA repair gene, that is mapped to human chromosome13q33. It is a member of the FEN-1 family of structure-specific nucleases and contains two highly conserved nuclease motifs known as the N and I regions separated by a large insertion. This gene spans around 69kb in length and has15 exons. It is highly polymorphic.

Immunogen

synthetic peptide corresponding to amino acids 1120-1137 of human XPG, conjugated to KLH via an N-terminal added cysteine residue.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Classe de stockage

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificats d'analyse (COA)

Lot/Batch Number
096M4806V
077K4767

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method
Shiomi N, et al.
Molecular and Cellular Biology, 24(9), 3712-3719 (2004)
Loss of heterozygosity and lack of mutations of the XPG/ERCC5 DNA repair gene at 13q33 in prostate cancer
Hyytinen ER, et al.
Prostate, 41(3), 190-195 (1999)
Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair
Seoane M, et al.
Oncogene, 38(19), 3616-3616 (2019)
Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity
Hohl M, et al.
Nucleic Acids Research, 35(9), 3053-3063 (2007)
XPG rs873601 G> A contributes to uterine leiomyoma susceptibility in a Southern Chinese population
Liu Z, et al.
Bioscience Reports, 38(5), BSR20181116-BSR20181116 (2018)
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Contenu apparenté

Data Sheet - X1629

Instructions

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