Z0153

ZM 241385

Name: ZM 241385
Brand: SIGMA

≥98% (HPLC), adenosine A2A antagonist, powder

Synonyme(s) :

4-(-2-[7-amino-2-{2-furyl}{1,2,4}triazolo{2,3-a} {1,3,5}triazin-5-yl-amino]ethyl)phenol

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About This Item

Formule empirique (notation de Hill) :

C₁₆H₁₅N₇O₂

Numéro CAS:

139180-30-6

Poids moléculaire :

337.34

UNSPSC Code:

12352200

PubChem Substance ID:

329831597

NACRES:

NA.77

MDL number:

MFCD00908394

Nom du produit

ZM 241385, ≥98% (HPLC)

SMILES string

Nc1nc(NCCc2ccc(O)cc2)nc3nc(nn13)-c4ccco4

InChI key

PWTBZOIUWZOPFT-UHFFFAOYSA-N

InChI

1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: >15 mg/mL

storage temp.

room temp

Quality Level

100

Catégories apparentées

Bioactive Small Molecules

Biochem/physiol Actions

ZM 241385 is a potent selective adenosine A2A antagonist.

ZM 241385 is a potent selective adenosine A2A antagonist. The A2A receptor plays a role in regulating myocardial oxygen consumption and coronary blood flow and is highly expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release. ZM 241385 has neuroprotective effects and is being investigated for use in Parkinson′s and other neurodegenerative disorders.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Consulter la Bibliothèque de documents

Potential therapeutic effects of antagonizing adenosine A2A receptor, curcumin and niacin in rotenone-induced Parkinson's disease mice model.

Tarek K Motawi et al.

Molecular and cellular biochemistry, 465(1-2), 89-102 (2019-12-11)

Parkinson's disease (PD) is the second common age-related neurodegenerative disease. It is characterized by control loss of voluntary movements control, resting tremor, postural instability, bradykinesia, and rigidity. The aim of the present work is to evaluate curcumin, niacin, dopaminergic and

Adenosine-mediated enteric neuromuscular function is affected during herpes simplex virus type 1 infection of rat enteric nervous system.

Chiara Zoppellaro et al.

PloS one, 8(8), e72648-e72648 (2013-09-10)

Adenosine plays an important role in regulating intestinal motility and inflammatory processes. Previous studies in rodent models have demonstrated that adenosine metabolism and signalling are altered during chronic intestinal inflammatory diseases. However, the involvement of the adenosinergic system in the

Effect of adenosine A(2A) receptor antagonists and L-DOPA on hydroxyl radical, glutamate and dopamine in the striatum of 6-OHDA-treated rats.

Krystyna Gołembiowska et al.

Neurotoxicity research, 21(2), 222-230 (2011-08-11)

A(2A) adenosine receptor antagonists have been proposed as a new therapy of PD. Since oxidative stress plays an important role in the pathogenesis of PD, we studied the effect of the selective A(2A) adenosine receptor antagonists 8-(-3-chlorostyryl)caffeine (CSC) and 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol

Suppression of Canine Dendritic Cell Activation/Maturation and Inflammatory Cytokine Release by Mesenchymal Stem Cells Occurs Through Multiple Distinct Biochemical Pathways.

William H Wheat et al.

Stem cells and development, 26(4), 249-262 (2016-11-16)

Mesenchymal stem cells (MSC) represent a readily accessible source of cells with potent immune modulatory activity. MSC can suppress ongoing inflammatory responses by suppressing T cell function, while fewer studies have examined the impact of MSC on dendritic cell (DC)

Number of Circulating CD 73-Expressing Lymphocytes Correlates With Survival After Cardiac Arrest.

Sergey Ryzhov et al.

Journal of the American Heart Association, 8(13), e010874-e010874 (2019-06-27)

Background Patients resuscitated from cardiac arrest ( CA ) have highly variable neurological, circulatory, and systemic ischemia-reperfusion injuries. After the initial hypoxic-ischemic insult, a cascade of immune and inflammatory responses develops and is often fatal. The role of the immune

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