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218710 Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem

218710
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CAS #Empirical Formula
934358-00-6C₉H₄Br₄O₂

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218710-5MG
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      Description
      OverviewA cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC50 = 7.7 µM). Also available as a 25 mM solution in DMSO (Cat. No. 218861).
      Catalogue Number218710
      Brand Family Calbiochem®
      Synonyms(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, CKII Inhibitor, TBCA
      References
      ReferencesPagano, M.A., et al. 2006. Chembiochem 8, 129
      Product Information
      CAS number934358-00-6
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₉H₄Br₄O₂
      Chemical formulaC₉H₄Br₄O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCasein Kinase II Inhibitor III, TBCA, CAS 934358-00-6, is a cell-permeable, potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM).
      Biological Information
      Primary TargetCasein Kinase II
      Primary Target IC<sub>50</sub>110 nM
      Primary Target K<sub>i</sub>77 nM against Casein Kinase II
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      218710

      Referencias bibliográficas

      Visión general referencias
      Pagano, M.A., et al. 2006. Chembiochem 8, 129
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2008 RFH
      Synonyms(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, CKII Inhibitor, TBCA
      DescriptionA cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC50 = 7.7 µM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number934358-00-6
      Chemical formulaC₉H₄Br₄O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml). Use only fresh DMSO.
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesPagano, M.A., et al. 2006. Chembiochem 8, 129