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324694 Emodin - CAS 518-82-1 - Calbiochem

324694
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Empirical FormulaCAS #
C₁₅H₁₀O₅ 518-82-1

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      Description
      OverviewA cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 µM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 15 µM). Also suppresses HER2/neu tyrosine kinase activity in HER2/neu overexpressing breast cancer cells.
      Catalogue Number324694
      Brand Family Calbiochem®
      Synonyms6-Methyl-1,3,8-trihydroxyanthraquinone
      References
      ReferencesPickhardt, M., et al. 2004. J. Biol. Chem. 280, 3628.
      Zhang, L., and Hung. M.C. 1996. Oncogene 12, 571.
      Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193, 1152.
      Jayasuriya, H., et al. 1992. J. Nat. Prod. 55, 696.
      Product Information
      CAS number518-82-1
      ATP CompetitiveN
      FormOrange solid
      Hill FormulaC₁₅H₁₀O₅
      Chemical formulaC₁₅H₁₀O₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetp56lck tyrosine kinase
      Primary Target IC<sub>50</sub>18.5 µM against p56lck tyrosine kinase
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSCB7920600
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous alkali; reconstitute just prior to use.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Emodin - CAS 518-82-1 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Emodin - CAS 518-82-1 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      324694

      Referencias bibliográficas

      Visión general referencias
      Pickhardt, M., et al. 2004. J. Biol. Chem. 280, 3628.
      Zhang, L., and Hung. M.C. 1996. Oncogene 12, 571.
      Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193, 1152.
      Jayasuriya, H., et al. 1992. J. Nat. Prod. 55, 696.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-January-2010 RFH
      Synonyms6-Methyl-1,3,8-trihydroxyanthraquinone
      DescriptionA cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 µM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 14.8 µM) without affecting normal human bronchial epithelial cells, even at a concentration of 370 mM. Reported to act as an inhibitor of Tau aggregation and aid in the disassembly of PHF in vitro and in vivo.
      FormOrange solid
      CAS number518-82-1
      RTECSCB7920600
      Chemical formulaC₁₅H₁₀O₅
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (1 mg/ml), Ethanol or Aqueous alkali
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous alkali; reconstitute just prior to use.
      Toxicity Standard Handling
      Merck USA index14, 3561
      ReferencesPickhardt, M., et al. 2004. J. Biol. Chem. 280, 3628.
      Zhang, L., and Hung. M.C. 1996. Oncogene 12, 571.
      Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193, 1152.
      Jayasuriya, H., et al. 1992. J. Nat. Prod. 55, 696.