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FCMAB209F Milli-Mark™ Anti-CD79β-FITC Antibody, clone SN8

Milli-Mark Anti-CD79β-FITC Antibody, clone SN8 detects level of CD79β & has been published & validated for use in FC.

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Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology UniProt Number: P40259
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FCMAB209F
100 tests  
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMFITCMonoclonal Antibody
      Description
      Catalogue NumberFCMAB209F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark™ Anti-CD79β-FITC Antibody, clone SN8
      Alternate Names
      • B-cell antigen receptor complex-associated protein beta chain
      • Ig-beta
      • B-cell-specific glycoprotein B29
      • Immunoglobulin-associated B29 protein
      Background InformationCD79beta is restricted to the B-cell lineage, and is found in pro-B cells before Ig heavy-chain gene rearrangement but after CD79alpha expression. The antibody reacts with an epitope on the extracellular domain of CD79 (Yoshida, 1995). Anti-CD79beta, SN8, was included in the Fifth International Workshop and Conference on Human Leucocyte Differentiation Antigens, and studies by a number of laboratories confirmed its reactivity with CD79beta (Engel, 1995; Persin, 1995).
      References
      Product Information
      FormatFITC
      Control
      • Human Lymphocytes
      PresentationPurified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
      Quality LevelMQ100
      Applications
      ApplicationMilli-Mark Anti-CD79β-FITC Antibody, clone SN8 detects level of CD79β & has been published & validated for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      CloneSN8
      HostMouse
      SpecificityAntibody recognizes Human CD79b antigen.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryRequired in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79B are a cause of hypogammaglobulinemia immunodeficiency and reduced B cells. Hypogammaglobulinemia is an immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood. The disorder results in a failure of B cell development in patients with immunodeficiency and is associated with a markedly reduced but not absent B cells.
      Molecular Weight36 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using human lymphocytess
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      FCMAB209F 04053252375484