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551600 Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem

551600
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Empirical FormulaCAS #
C₁₅H₁₀O₇ · 2H₂O 6151-25-3

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      Description
      OverviewA cell-permeable and reversible inhibitor of PIM1 kinase (IC50 = 43 nM), PI 3-K (IC50 = 3.8 µM) and phospholipase A2 (IC50 = 2 µM). Also inhibits mitochondrial ATPase, phosphodiesterases, and protein kinase C. Induces apoptosis in K562, Molt-4, Raji, and MCAS tumor cell lines. Reported to activate sirtuins and promote the survival of eukaryotic cells.
      Catalogue Number551600
      Brand Family Calbiochem®
      Synonyms3,3ʹ,4ʹ,5,7-Pentahydroxyflavone
      References
      ReferencesBullock, A.N., et al. 2005. J. Med. Chem. 48, 7604.
      Howitz, K.T., et al. 2003. Nature 425, 191.
      Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952.
      Shibasaki, F., et al. 1993. Biochem. J. 289, 227.
      Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624.
      Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227.
      Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583.
      Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444.
      Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535.
      Beretz, A., et al. 1978. Experientia 34, 1054.
      Product Information
      CAS number6151-25-3
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₅H₁₀O₇ · 2H₂O
      Chemical formulaC₁₅H₁₀O₇ · 2H₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPI 3-kinase
      Primary Target IC<sub>50</sub>43 nM, 3.8 µM, 2 µM against PIM1 kinase, PI 3-K, and phospholipase A2, respectively
      Purity>95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSLK8950000
      Safety Information
      R PhraseR: 25-40

      Toxic if swallowed.
      Limited evidence of a carcinogenic effect.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      551600

      Referencias bibliográficas

      Visión general referencias
      Bullock, A.N., et al. 2005. J. Med. Chem. 48, 7604.
      Howitz, K.T., et al. 2003. Nature 425, 191.
      Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952.
      Shibasaki, F., et al. 1993. Biochem. J. 289, 227.
      Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624.
      Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227.
      Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583.
      Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444.
      Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535.
      Beretz, A., et al. 1978. Experientia 34, 1054.

      Folleto

      Cargo
      Caspases and other Apoptosis Related Tools Brochure
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-June-2009 JSW
      Synonyms3,3ʹ,4ʹ,5,7-Pentahydroxyflavone
      DescriptionA cell-permeable inhibitor of PIM1 kinase (IC50 = 43 nM), PI 3-K (IC50 = 3.8 µM) and phospholipase A2 (IC50 = 2 µM). Also inhibits mitochondrial ATPase, phosphodiesterases, and protein kinase C. Induces apoptosis in K562, Molt-4, Raji, and MCAS tumor cell lines. Reported to activate sirtuins and promote the survival of eukaryotic cells.
      FormYellow solid
      CAS number6151-25-3
      RTECSLK8950000
      Chemical formulaC₁₅H₁₀O₇ · 2H₂O
      Structure formulaStructure formula
      Purity>95% by HPLC
      SolubilityAcetic Acid (1 mg/ml), Aqueous Alkali (1 mg/ml), or DMSO (5 mg/ml)
      Storage +15°C to +30°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
      Toxicity Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 8034
      ReferencesBullock, A.N., et al. 2005. J. Med. Chem. 48, 7604.
      Howitz, K.T., et al. 2003. Nature 425, 191.
      Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952.
      Shibasaki, F., et al. 1993. Biochem. J. 289, 227.
      Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624.
      Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227.
      Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583.
      Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444.
      Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535.
      Beretz, A., et al. 1978. Experientia 34, 1054.