333786
L-Dopa-(phenyl-d3)
≥98 atom % D, ≥98% (CP)
Synonym(s):
3-(3,4-Dihydroxyphenyl-2,5,6-d3)-L-alanine
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About This Item
Linear Formula:
(HO)2C6D3CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
200.21
NACRES:
NA.12
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Isotopic purity:
≥98 atom % D
Assay:
≥98% (CP)
Mass shift:
M+3
Form:
powder
isotopic purity
≥98 atom % D
Quality Level
assay
≥98% (CP)
form
powder
optical activity
[α]27/D −11.5°, c = 5 in 1 M HCl
technique(s)
mass spectrometry (MS): suitable
mp
292 °C (dec.) (lit.)
mass shift
M+3
storage temp.
2-8°C
SMILES string
[2H]c1c([2H])c(C[C@H](N)C(O)=O)c([2H])c(O)c1O
InChI
1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1/i1D,2D,4D
InChI key
WTDRDQBEARUVNC-UOCCHMHCSA-N
General description
L-Dopa-(phenyl-d3) is an isotopic analogue of 3-(3,4-Dihydroxyphenyl)-L-alanine amino acid.
Application
L-Dopa-(phenyl-d3) can be used as an internal standard.
L-Dopa-(phenyl-d3) or (3-(3,4-dihydroxyphenyl-2,5,6-d3)-L-alanine) can be used as an internal standard for the quantification of methyldopa in human plasma by LC-MS-MS based method.
Packaging
This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Glauber de S Araujo et al.
PloS one, 7(1), e29561-e29561 (2012-01-19)
Capsule production is common among bacterial species, but relatively rare in eukaryotic microorganisms. Members of the fungal Cryptococcus genus are known to produce capsules, which are major determinants of virulence in the highly pathogenic species Cryptococcus neoformans and Cryptococcus gattii.
Celso H Oliveira et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 768(2), 341-348 (2002-03-13)
A method based on LC-MS-MS is described for the determination of methyldopa in human plasma using dopa-phenyl-D3 as the internal standard. The method has a chromatographic run time of 5.5 min and was linear in the range of 20-5000 ng/ml.
Dario Breitel et al.
Metabolic engineering, 65, 185-196 (2020-11-27)
L-DOPA, also known as Levodopa or L-3,4-dihydroxyphenylalanine, is a non-standard amino acid, and the gold standard drug for the treatment for Parkinson's Disease (PD). Recently, a gene encoding the enzyme that is responsible for its synthesis, as a precursor of