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122302 ω-Agatoxin TK, Agelenopsis aperta

Specific P-type calcium channel blocker with no apparent effect on L-type, N-type, and T-type channels.

ω-Agatoxin TK, Agelenopsis aperta MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ω-Aga-TK

Primary Target: Specific P-type calcium channel blocker
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      145017-83-0C₂₁₅H₃₃₇N₆₅O₇₀S₁₀
      Description
      Overview

      This product has been discontinued.





      Specific P-type calcium channel blocker with no apparent effect on L-type, N-type, and T-type channels. Useful tool for investigating the role of P-type calcium channels in the peripheral and central nervous systems. Also inhibits the release of amino acid transmitters and monoamines.
      Catalogue Number122302
      Brand Family Calbiochem®
      Synonymsω-Aga-TK
      References
      ReferencesKimura, M., et al. 1995. Neuroscience 66, 609.
      Teramoto, T., et al. 1995. NeuroReport 6, 1684.
      Teramoto, T., et al. 1993. Biochem. Biophys. Res. Commun. 196, 134.
      Product Information
      CAS number145017-83-0
      ATP CompetitiveN
      FormLyophilized
      Hill FormulaC₂₁₅H₃₃₇N₆₅O₇₀S₁₀
      Chemical formulaC₂₁₅H₃₃₇N₆₅O₇₀S₁₀
      ReversibleN
      Applications
      Biological Information
      Biological activityShown to inhibit K+-induced ³H-GABA release from primary rat hippocampal neurons
      Primary TargetSpecific P-type calcium channel blocker
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Glu-Asp-Asn-Cys⁴-Ile-Ala-Glu-Asp-Tyr-Gly-Lys-Cys¹²-Thr-Trp-Gly-Gly-Thr-Lys-Cys¹⁹-Cys²⁰-Arg-Gly-Arg-Pro-Cys²⁵-Arg-Cys²⁷-Ser-Met-Ile-Gly-Thr-Asn-Cys³⁴-Glu-Cys³⁶-Thr-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Ser-Phe-Ala-OH (disulfide bonds: 4 → 20; 12 → 25; 19 → 36; 27 → 34)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. This product is stable for up to 1 week at 4°C or for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      122302 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      ω-Agatoxin TK, Agelenopsis aperta Certificates of Analysis

      TitleLot Number
      122302

      References

      Reference overview
      Kimura, M., et al. 1995. Neuroscience 66, 609.
      Teramoto, T., et al. 1995. NeuroReport 6, 1684.
      Teramoto, T., et al. 1993. Biochem. Biophys. Res. Commun. 196, 134.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-April-2008 RFH
      Synonymsω-Aga-TK
      DescriptionSpecific P-type calcium channel blocker with no apparent effect on L-type, N-type, and T-type channels. Useful tool for investigating the role of P-type calcium channels in the peripheral and central nervous systems. Also inhibits the release of amino acid transmitters and monoamines.
      FormLyophilized
      CAS number145017-83-0
      Chemical formulaC₂₁₅H₃₃₇N₆₅O₇₀S₁₀
      Peptide SequenceH-Glu-Asp-Asn-Cys⁴-Ile-Ala-Glu-Asp-Tyr-Gly-Lys-Cys¹²-Thr-Trp-Gly-Gly-Thr-Lys-Cys¹⁹-Cys²⁰-Arg-Gly-Arg-Pro-Cys²⁵-Arg-Cys²⁷-Ser-Met-Ile-Gly-Thr-Asn-Cys³⁴-Glu-Cys³⁶-Thr-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Ser-Phe-Ala-OH (disulfide bonds: 4 → 20; 12 → 25; 19 → 36; 27 → 34)
      Purity≥99% by HPLC
      Biological activityShown to inhibit K+-induced ³H-GABA release from primary rat hippocampal neurons
      SolubilityH₂O (1 mg/ml) or 0.9% NaCl (1 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. This product is stable for up to 1 week at 4°C or for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesKimura, M., et al. 1995. Neuroscience 66, 609.
      Teramoto, T., et al. 1995. NeuroReport 6, 1684.
      Teramoto, T., et al. 1993. Biochem. Biophys. Res. Commun. 196, 134.