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505414 (±)-Epibatidine dihydrochloride - CAS 501684-93-1 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane, Nicotinic Acetylcholine Receptors (nAChR) Agonist, Epibatidine

Primary Target: nAChR
505414
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      501684-93-1C₁₁H₁₃ClN₂•2HCl•xH2O
      Description
      Overview

      This product has been discontinued.



      The most potent agonist known for nicotinic acetylcholine receptors (nAChR, Ki = 0.045 and 0.058 nM for natural (+) enantiomer and (-) enantiomer, respectively). Widely used for studying the functional roles of nAChRs in brain.
      Catalogue Number505414
      Brand Family Calbiochem®
      Synonyms2-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane, Nicotinic Acetylcholine Receptors (nAChR) Agonist, Epibatidine
      References
      ReferencesDecker, W., et al., 1999. Biochem. Pharmacol. 58, 917.
      Gerzanich, V., et al., 1995. Mol. Pharmacol. 48, 774.
      Spande,X., et al., 1992. J. Am. Chem. Soc. 114, 3475.
      Product Information
      CAS number501684-93-1
      FormWhite powder
      Hill FormulaC₁₁H₁₃ClN₂•2HCl•xH2O
      Chemical formulaC₁₁H₁₃ClN₂•2HCl•xH2O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetnAChR
      Primary Target K<sub>i</sub>0.045 nM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      505414 0

      Documentation

      References

      Reference overview
      Decker, W., et al., 1999. Biochem. Pharmacol. 58, 917.
      Gerzanich, V., et al., 1995. Mol. Pharmacol. 48, 774.
      Spande,X., et al., 1992. J. Am. Chem. Soc. 114, 3475.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2013 JSW
      Synonyms2-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane, Nicotinic Acetylcholine Receptors (nAChR) Agonist, Epibatidine
      DescriptionThe most potent agonist known for nicotinic acetylcholine receptors (nAChR, Ki = 0.045 and 0.058 nM for natural (+) enantiomer and (-) enantiomer, respectively). Widely used for studying the functional roles of nAChRs in brain.
      FormWhite powder
      CAS number501684-93-1
      Chemical formulaC₁₁H₁₃ClN₂•2HCl•xH2O
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (4 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDecker, W., et al., 1999. Biochem. Pharmacol. 58, 917.
      Gerzanich, V., et al., 1995. Mol. Pharmacol. 48, 774.
      Spande,X., et al., 1992. J. Am. Chem. Soc. 114, 3475.