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565750 γ-Secretase Inhibitor I - Calbiochem

The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

γ-Secretase Inhibitor I - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-LLNle-CHO

Primary Target: γ-secretase
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565750
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₆H₄₁N₃O₅

Pricing & Availability

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565750-1MG
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      		 Plastic ampoule 1 mg
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      Description
      OverviewCell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer’s disease.
      Catalogue Number565750
      Brand Family Calbiochem®
      SynonymsZ-LLNle-CHO
      References
      ReferencesSkovronsky, D.M., et al. 2000. Biochemistry 39, 810.
      Hartmann, T., et al. 1997. Nat. Med. 3, 1016.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₆H₄₁N₃O₅
      Chemical formulaC₂₆H₄₁N₃O₅
      HS Code2924 29 99
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Primary Targetγ-secretase
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Leu-Leu-Nle-CHO (Nle = Norleucine)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      565750-1MG 04055977267679

      Documentation

      γ-Secretase Inhibitor I - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      γ-Secretase Inhibitor I - Calbiochem Certificates of Analysis

      TitleLot Number
      565750

      References

      Reference overview
      Skovronsky, D.M., et al. 2000. Biochemistry 39, 810.
      Hartmann, T., et al. 1997. Nat. Med. 3, 1016.

      Brochure

      Title
      Stem Cell Resource Brochure GBP
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-January-2009 RFH
      SynonymsZ-LLNle-CHO
      DescriptionInhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer's disease.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₆H₄₁N₃O₅
      Peptide SequenceZ-Leu-Leu-Nle-CHO (Nle = Norleucine)
      Structure formulaStructure formula
      Purity≥90% by HPLC
      Solubility50% acetic acid or DMSO (10 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSkovronsky, D.M., et al. 2000. Biochemistry 39, 810.
      Hartmann, T., et al. 1997. Nat. Med. 3, 1016.