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565749 β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem

The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal

Primary Target: β-secretase
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      263563-09-3C₂₅H₃₉N₃O₅
      Description
      OverviewA potent, cell-permeable, and reversible inhibitor of β-secretase. Corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stable transfected with wild-type APP751.
      Catalogue Number565749
      Brand Family Calbiochem®
      SynonymsZ-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
      References
      ReferencesAbbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.
      Product Information
      CAS number263563-09-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₅H₃₉N₃O₅
      Chemical formulaC₂₅H₃₉N₃O₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetβ-secretase
      Primary Target IC<sub>50</sub>700 nM and 2.5 µM against Aβtotal and Aβ1-42, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Val-Leu-Leu-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      565749 0

      Documentation

      β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      565749

      References

      Reference overview
      Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      SynonymsZ-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
      DescriptionA potent, cell-permeable, and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number263563-09-3
      Chemical formulaC₂₅H₃₉N₃O₅
      Peptide SequenceZ-Val-Leu-Leu-CHO
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAbbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.