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565751 α-Secretase Substrate I, Fluorogenic

α-Secretase Substrate I, Fluorogenic MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MCA-HQKLVFFAK(DNP)-NH₂

565751
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      We are offering α-Secretase Substrate II, Fluorogenic (Cat. No. 565767) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.





      A specific fluorescent resonance energy transfer (FRET) substrate for the detection of α-secretase activity.
      Catalogue Number565751
      Brand Family Calbiochem®
      SynonymsMCA-HQKLVFFAK(DNP)-NH₂
      References
      ReferencesFarzan, M., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9712.
      Kowalewski, T. and Holtzman, D.M. 1999. Proc. Natl. Acad. Sci. USA 96, 3688.
      Komano, H., et al. 1998. J. Biol. Chem. 273, 31648.
      Ladror, U.S., et al. 1994. J. Protein. Chem. 13, 357.
      Product Information
      FormLiquid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₇₃H₉₄N₁₆O₁₉
      Chemical formulaC₇₃H₉₄N₁₆O₁₉
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Emission max.
      Excitation max.
      Peptide SequenceMCA-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys(DNP)-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      565751 0

      Documentation

      References

      Reference overview
      Farzan, M., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9712.
      Kowalewski, T. and Holtzman, D.M. 1999. Proc. Natl. Acad. Sci. USA 96, 3688.
      Komano, H., et al. 1998. J. Biol. Chem. 273, 31648.
      Ladror, U.S., et al. 1994. J. Protein. Chem. 13, 357.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 RFH
      SynonymsMCA-HQKLVFFAK(DNP)-NH₂
      DescriptionA specific fluorescent resonance energy transfer (FRET) peptide substrate for the detection of α-secretase activity. Cleavage occurs between lysine and leucine. Excitation max: ~325 nm; emission max: ~393 nm.
      FormLiquid
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₇₃H₉₄N₁₆O₁₉
      Peptide SequenceMCA-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys(DNP)-NH₂
      Purity≥95% by HPLC
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesFarzan, M., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9712.
      Kowalewski, T. and Holtzman, D.M. 1999. Proc. Natl. Acad. Sci. USA 96, 3688.
      Komano, H., et al. 1998. J. Biol. Chem. 273, 31648.
      Ladror, U.S., et al. 1994. J. Protein. Chem. 13, 357.