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565782 β-Secretase Substrate VII, Fluorogenic

β-Secretase Substrate VII, Fluorogenic MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: JMV2235, Abz-VKM~DAE-EDDnp

565782
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.





      An internally quenched fluorogenic peptide substrate designed from wild-type β-APP (β-amyloid precursor protein) sequence that selectively detects BACE1 (β-secretase 1), BACE2, and cathepsin D. Cleavage occurs between Met-Asp residues, which results in fluorescence enhancement. Also useful for screening of inhibitors for BACE1, BACE2, and cathepsin D.
      Catalogue Number565782
      Brand Family Calbiochem®
      SynonymsJMV2235, Abz-VKM~DAE-EDDnp
      References
      ReferencesAndrau, D., et al. 2003. J. Biol. Chem. 278, 25859.
      Product Information
      FormLyophilized yellow solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₄₃H₆₂N₁₂O₁₅S
      Chemical formulaC₄₃H₆₂N₁₂O₁₅S
      Hygroscopic Hygroscopic
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Peptide SequenceAbz-Val-Lys-Met~Asp-Ala-Glu-EDDnp
      Abz = 2-Aminobenzoyl; EDDnp = N-(2,4-dinitrophenyl)ethylenediamine
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      565782 0

      Documentation

      References

      Reference overview
      Andrau, D., et al. 2003. J. Biol. Chem. 278, 25859.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 RFH
      SynonymsJMV2235, Abz-VKM~DAE-EDDnp
      DescriptionAn internally quenched fluorogenic peptide substrate derived from the wild-type β-amyloid precursor protein (β-APP) sequence that selectively detects β-secretase 1 (BACE1), BACE2, and cathepsin D. Cleavage occurs at the Met~Asp junction and results in enhanced fluorescence. Useful for assessing activity as well as screening inhibitors of BACE1, BACE2, and cathepsin D. Excitation max: ~320 nm; emission max: ~420 nm.
      FormLyophilized yellow solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₄₃H₆₂N₁₂O₁₅S
      Peptide SequenceAbz-Val-Lys-Met~Asp-Ala-Glu-EDDnp
      Abz = 2-Aminobenzoyl; EDDnp = N-(2,4-dinitrophenyl)ethylenediamine
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesAndrau, D., et al. 2003. J. Biol. Chem. 278, 25859.