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530583 α-Synuclein Blocker, ELN484228 - CAS 312-63-0 - Calbiochem

A cell-permeable compound that reversibly binds to pocket I of the monomeric α-synuclein (α-syn) and reverses α-syn-induced impairment of phagocytosis in H4 neuroglioma cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-Fluorophenyl)benzenesulfonamide, NSC164389, ELN 484228

Primary Target: monomeric α-synuclein
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530583
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
312-63-0C₁₂H₁₀FNO₂S

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      Description
      OverviewA cell-permeable phenylsulfonamide compound that reversibly binds to pocket I of the monomeric α-synuclein (α-syn) and reverses α-syn-induced impairment of phagocytosis in H4 neuroglioma cells over-expressing wild-type α-syn and microglia isolated from α-syn BAC transgenic animals over-expressing the E46K mutant form of human α-syn (~1-10 µM). Reduces α-syn-mediated impairment of vesicular dynamics and diminishes α-syn translocation to the synaptic region in rat primary neuronal cultures by 50% (at ~ 1 µM) and in cortical cultures in transgenic mice over-expressing human α-syn. Also shown to protect dopaminergic neurons against the toxic effects of over-expressed α-syn A53T and reduces neurite retraction in TH- and MAP2-positive neurons.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530583
      Brand Family Calbiochem®
      SynonymsN-(4-Fluorophenyl)benzenesulfonamide, NSC164389, ELN 484228
      References
      ReferencesToth, G., et al. 2014. PLoS ONE 9, e87133.
      Product Information
      CAS number312-63-0
      FormOff-white solid
      Hill FormulaC₁₂H₁₀FNO₂S
      Chemical formulaC₁₂H₁₀FNO₂S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetmonomeric α-synuclein
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.30583.0001 04055977260915

      Documentation

      α-Synuclein Blocker, ELN484228 - CAS 312-63-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Toth, G., et al. 2014. PLoS ONE 9, e87133.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-May-2014 JSW
      SynonymsN-(4-Fluorophenyl)benzenesulfonamide, NSC164389, ELN 484228
      DescriptionA cell-permeable phenylsulfonamide compound that reversibly binds to pocket I of the monomeric α-synuclein (α-syn) and reverses α-syn-induced impairment of phagocytosis in H4 neuroglioma cells over-expressing wild-type α-syn and microglia isolated from α-syn BAC transgenic animals over-expressing the E46K mutant form of human α-syn (~1-10 µM). Reduces α-syn-mediated impairment of vesicular dynamics and diminishes α-syn translocation to the synaptic region in rat primary neuronal cultures by 50% (at ~ 1 µM) and in cortical cultures in transgenic mice over-expressing human α-syn. Also shown to protect dopaminergic neurons against the toxic effects of over-expressed α-syn A53T and reduces neurite retraction in TH- and MAP2-positive neurons.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number312-63-0
      Chemical formulaC₁₂H₁₀FNO₂S
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesToth, G., et al. 2014. PLoS ONE 9, e87133.