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658510 AG 1288

AG 1288 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-Cyano-(3,4-dihydroxy-5-nitro)cinnamonitrile

658510
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      Please refer to our complete listing of protein tyrosine kinase inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





      A cell-permeable compound shown to actively block TNF-α induced cytotoxicity. Has properties similar to AG 126 (Cat. No. 658452). Blocks the glucocorticoid-induced COX-2 activity in human amnion cells (IC50 = 21 µM).
      Catalogue Number658510
      Brand Family Calbiochem®
      Synonymsα-Cyano-(3,4-dihydroxy-5-nitro)cinnamonitrile
      References
      ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247. Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol. 77, 138. Novogrodsky, A., et al. 1994. Science 264, 1319.
      Product Information
      CAS number116313-73-6
      FormOrange-yellow solid
      Hill FormulaC₁₀H₅N₃O₄
      Chemical formulaC₁₀H₅N₃O₄
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      658510 0

      Documentation

      References

      Reference overview
      Jaleel, M., et al. 2004. Biochemistry 43, 8247. Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol. 77, 138. Novogrodsky, A., et al. 1994. Science 264, 1319.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-September-2008 RFH
      Synonymsα-Cyano-(3,4-dihydroxy-5-nitro)cinnamonitrile
      DescriptionShown to actively block tumor necrosis factor-α induced cytotoxicity. Has properties similar to AG 126 (Cat. No. 658452). Also reported to inhibit guanylyl cyclase.
      FormOrange-yellow solid
      CAS number116313-73-6
      Chemical formulaC₁₀H₅N₃O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or DMF
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247. Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol. 77, 138. Novogrodsky, A., et al. 1994. Science 264, 1319.