155306 AMPA Agonist, CMPA - Calbiochem

155306
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₆H₂₈N₂O₄S₂

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155306-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA bisalykylsulfonamide that acts as a positive, allosteric modulator against AMPA receptors (EC50 = 45 nM and 63 nM for GluA2i and GluA2o, respectively) in a HEK 293 calcium FLIPR assay. At 10 µM, it robustly modulates receptor desensitization of both the flip (GluA2i) and flop (GluA2o) isoforms of GluA2 receptors in transfected HEK 293 cells with higher potency and efficacy than two other distinct AMPA modulators, cyclothiazide and CX614. Using a ligand bound crystal structure, it is shown to bind to the dimer interface of the extracellular ligand-binding domain of AMPA receptors, a region that partially overlaps with binding pockets for cyclothiazide and CX614.
      Catalogue Number155306
      Brand Family Calbiochem®
      SynonymsN,Nʹ-(2,2ʹ-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonamide, AMPA Activator
      References
      ReferencesTimm, D., et al. 2011. Mol. Pharm. 80, 267.
      Product Information
      FormOff-white powder
      Hill FormulaC₁₆H₂₈N₂O₄S₂
      Chemical formulaC₁₆H₂₈N₂O₄S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AMPA Agonist, CMPA - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      AMPA Agonist, CMPA - Calbiochem Certificates of Analysis

      TitleLot Number
      155306

      References

      Reference overview
      Timm, D., et al. 2011. Mol. Pharm. 80, 267.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-July-2012 JSW
      SynonymsN,Nʹ-(2,2ʹ-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonamide, AMPA Activator
      DescriptionA bisalykylsulfonamide that acts as a positive, allosteric modulator against AMPA receptors (EC50 = 45 nM and 63 nM for GluA2i and GluA2o, respectively) in a HEK 293 calcium FLIPR assay. At 10 µM, it robustly modulates receptor desensitization of both the flip (GluA2i) and flop (GluA2o) isoforms of GluA2 receptors in transfected HEK 293 cells with higher potency and efficacy than two other distinct AMPA modulators, cyclothiazide and CX614. Using a ligand bound crystal structure, it is shown to bind to the dimer interface of the extracellular ligand-binding domain of AMPA receptors, a region that partially overlaps with binding pockets for cyclothiazide and CX614.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₆H₂₈N₂O₄S₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml; clear, nearly colorless solution)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTimm, D., et al. 2011. Mol. Pharm. 80, 267.