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119149 Adenosine A2A Receptor Antagonist I, ZM 241385 - CAS 139180-30-6 - Calbiochem

A highly potent, selective, non-xanthine adenosine A2A receptor antagonist (Ki = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino)ethyl)phenol, ZM-241385, ZM241385

Primary Target: A2A
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119149
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
139180-30-6C₁₆H₁₅N₇O₂

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      Description
      OverviewA highly potent, selective, and orally bioavailable non-xanthine adenosine A2A receptor antagonist (Ki = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells). Does not exhibit any significant antagonistic activity in A1, A2B (Ki = 255 nM and 50 nM, respectively in human adenosine receptors stably expressed in CHO cells) or in A3R (Ki > 10 µM in human A3R stably expressed in HEK-293 cells). Shown to have a protective effect against beta-amyloid peptide toxicity.
      Catalogue Number119149
      Brand Family Calbiochem®
      Synonyms4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino)ethyl)phenol, ZM-241385, ZM241385
      References
      ReferencesPoucher, S. M., et al. 1995. Brit. J. Pharmacol. 115, 1096.
      Ongini, E. et al. 1999. Naunyn Schmiedebergs Arch Pharmacol. 359, 7.
      Keddie, J. et al. 1996, Eur Journ Pharm. 301, 107.
      Product Information
      CAS number139180-30-6
      FormWhite to beige powder
      Hill FormulaC₁₆H₁₅N₇O₂
      Chemical formulaC₁₆H₁₅N₇O₂
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetA2A
      Primary Target K<sub>i</sub>800 pM
      Purity≥97.5% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      119149-5MG 04055977223385

      Documentation

      Adenosine A2A Receptor Antagonist I, ZM 241385 - CAS 139180-30-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      119149

      References

      Reference overview
      Poucher, S. M., et al. 1995. Brit. J. Pharmacol. 115, 1096.
      Ongini, E. et al. 1999. Naunyn Schmiedebergs Arch Pharmacol. 359, 7.
      Keddie, J. et al. 1996, Eur Journ Pharm. 301, 107.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-December-2019 JSW
      Synonyms4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino)ethyl)phenol, ZM-241385, ZM241385
      DescriptionA highly potent, selective, and orally bioavailable non-xanthine adenosine A2A receptor antagonist (Ki = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells). Does not exhibit any significant antagonistic activity in A1, A2B (Ki = 255 nM and 50 nM, respectively in human adenosine receptors stably expressed in CHO cells) or in A3R (Ki > 10 µM in human A3R stably expressed in HEK-293 cells). Shown to have a protective effect against beta-amyloid peptide toxicity.
      FormWhite to beige powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number139180-30-6
      Chemical formulaC₁₆H₁₅N₇O₂
      Purity≥97.5% by HPLC
      SolubilityDMSO (≥15 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPoucher, S. M., et al. 1995. Brit. J. Pharmacol. 115, 1096.
      Ongini, E. et al. 1999. Naunyn Schmiedebergs Arch Pharmacol. 359, 7.
      Keddie, J. et al. 1996, Eur Journ Pharm. 301, 107.