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15-205 Amyloid Beta Precursor Proteins Explorer Antibody MiniPack

This Antibody pack contains Anti-Alzheimer Precursor Protein A4, Anti-Alzheimer Precursor Protein, APP 643-695 C-terminal, Anti-Amyloid Precursor Protein, C-terminus.

Research Category: Neuroscience Research Sub-Category: Alzheimer's Disease, Neurodegenerative Diseases Gene Symbol: APP, PN-II, AD1, ABETA, CTFgamma, APPI, ABPP, A4, CVAP, PN2, PreA4, AAA UniProt Number: P05067
15-205
3 vials/Pk  
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      Description
      Catalogue Number15-205
      Trade Name
      • Upstate
      DescriptionAmyloid Beta Precursor Proteins Explorer Antibody MiniPack
      Background InformationPathway Explorer Antibody MiniPack:
      Each Pathway Explorer Antibody Minipack contains three related antibodies as part of a signaling cascade or a combination of total and phosphorylated forms of key signaling targets. Each of the three antibodies are 30% the original pack size. Full size versions of each of the Pathway Explorer antibodies are available for sale individually under the same catalog number with the removal of “SP” off of each one (e.g. 05-591SP can be ordered as 05-591).

      Alzheimer Precursor Protein A4, clone 22C11:
      Deposits of amyloid protein in senile plaques near nerve processes are found in the brains of aged humand and cases of Alzheimer's Disease. The principle component of this extracellular amyloid is beta/A4, a 4 kDa peptide derived from a larger amyloid precursor protein (APP), which is widely expressed in the brain and body. The creation, transport and function of these proteins are currently under investigation.

      * see full size version for corresponding references.
      References
      Product Information
      Components
      • MAB348SP Anti-Alzheimer Precursor Protein A4, clone 22C11: 15 μg
      • MAB343SP Anti-Alzheimer Precursor Protein, APP 643-695 C-terminal fragment, Clone 2.F2.19B4; 30 μL
      • AB5352SP Anti-Amyloid Precursor Protein, C-terminus; 30 μL
      Presentation3 individual tubes containing either Anti-Amyloid Precursor Protein, C-terminus; Anti-Alzheimer Precursor Protein, APP 643-695 C-terminal fragment, Clone 2.F2.19B4; or Anti-Alzheimer Precursor Protein A4, clone 22C11

      PropertiesEach vial is 30% the size of the parent catalog number
      Quality LevelMQ100
      Applications
      ApplicationThis Antibody pack contains Anti-Alzheimer Precursor Protein A4, Anti-Alzheimer Precursor Protein, APP 643-695 C-terminal, Anti-Amyloid Precursor Protein, C-terminus.
      Biological Information
      Cross ReactivityVaries. See individual Data Sheets
      Entrez Gene Number
      Gene Symbol
      • APP
      • PN-II
      • AD1
      • ABETA
      • CTFgamma
      • APPI
      • ABPP
      • A4
      • CVAP
      • PN2
      • PreA4
      • AAA
      UniProt Number
      UniProt SummaryFUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1/Tip60 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity.
      FUNCTION: Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity.
      FUNCTION: Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain (By similarity).
      FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
      SUBUNIT: Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1 and, Numb and Dab1 (By similarity). Binding to Dab1 inhibits its serine phosphorylation (By similarity). Also interacts with GPCR-like protein BPP, FPRL1, APPBP1, IB1, KNS2 (via its TPR domains) (By similarity), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains (By similarity). Associates with microtubules in the presence of ATP and in a kinesin-dependent manner (By similarity). Interacts, through a C-terminal domain, with GNAO1. Amyloid beta-42 binds CHRNA7 in hippocampal neurons. Beta-amyloid associates with HADH2. Soluble APP binds, via its N-terminal head, to FBLN1. Interacts with CPEB1 (By similarity). Interacts with ANKS1B.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size3 vials/Pk
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      15-205 04053252005350

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