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DR1001 Anti-8-Hydroxyguanosine Goat pAb

This Anti-8-Hydroxyguanosine Goat polyclonal antibody detects 8-Hydroxydeoxyguanosine in Alzheimer's disease brain tissue. It is validated for use in ELISA and with paraffin sections.

Anti-8-Hydroxyguanosine Goat pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-8-OHG, Anti-8-oxo-G

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DR1001
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Overview

Replacement Information

Key Spec Table

Species ReactivityHostAntibody Type
A Broad Range Of SpeciesGtPolyclonal Antibody

Pricing & Availability

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DR1001-100UL
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      Description
      OverviewRecognizes 8-Hydroxydeoxyguanosine in Alzheimer's disease brain tissue.
      Catalogue NumberDR1001
      Brand Family Calbiochem®
      SynonymsAnti-8-OHG, Anti-8-oxo-G
      Application Data
      Detection of 8-hydroxyguanosine in oxidized RNA by staining paraffin sections. Sample: Alzheimer's disease brain tissue formalin-fixed, paraffin-embedded and left untreated (left panel) or pretreated with 10 µg/ml proteinase K for 40 min at 37°C (right panel). Primary antibody: Anti-8-Hydroxyguanosine Goat pAb (Cat. No. DR1001) (1:200). Detection: DAB.
      References
      ReferencesAbe, T., et al. 2003. Neurosci. Lett. 336, 105.
      Parker, A.R., et al. 2002. Cancer Res. 62, 7230.
      Product Information
      FormLiquid
      FormulationUndiluted serum.
      Positive controlAlzheimer’s disease brain tissue
      PreservativeNone
      Quality LevelMQ100
      Applications
      Application ReferencesParaffin Sections Barouch, L.A., et al. 2006. Circ. Res. 98, 119.
      Key Applications Paraffin Sections
      Application NotesELISA (≥1:250,000)
      Paraffin Sections (≥1:200, proteinase K pre-treatment recommended; see figure legend, see application references)
      Application CommentsDoes not cross-react with other naturally occurring nucleotides. Antibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogen8-Hydroxyguanosine
      HostGoat
      IsotypeIgG
      Species Reactivity
      • A Broad Range Of Species
      Antibody TypePolyclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      DR1001-100UL 04055977225884

      Documentation

      Anti-8-Hydroxyguanosine Goat pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-8-Hydroxyguanosine Goat pAb Certificates of Analysis

      TitleLot Number
      DR1001

      References

      Reference overview
      Abe, T., et al. 2003. Neurosci. Lett. 336, 105.
      Parker, A.R., et al. 2002. Cancer Res. 62, 7230.

      Citations

      Title
    • Barouch, L.A., et al. 2006. Circulation Research 98, 119.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-August-2007 RFH
      SynonymsAnti-8-OHG, Anti-8-oxo-G
      ApplicationELISA (≥1:250,000)
      Paraffin Sections (≥1:200, proteinase K pre-treatment recommended; see figure legend, see application references)
      Application Data
      Detection of 8-hydroxyguanosine in oxidized RNA by staining paraffin sections. Sample: Alzheimer's disease brain tissue formalin-fixed, paraffin-embedded and left untreated (left panel) or pretreated with 10 µg/ml proteinase K for 40 min at 37°C (right panel). Primary antibody: Anti-8-Hydroxyguanosine Goat pAb (Cat. No. DR1001) (1:200). Detection: DAB.
      DescriptionGoat polyclonal antibody supplied as undiluted serum. Recognizes 8-hydroxydeoxy-guanosine.
      Background8-Hydroxydeoxy-guanosine is a modified base that occurs in DNA due to attack by reactive oxygen species. Increases in the levels of 8-hydroxyguanosine have been associated with several diseases in humans, such as arteriosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease.
      HostGoat
      Immunogen8-Hydroxyguanosine
      IsotypeIgG
      Speciesa broad range of species
      Positive controlAlzheimer’s disease brain tissue
      FormLiquid
      FormulationUndiluted serum.
      PreservativeNone
      CommentsDoes not cross-react with other naturally occurring nucleotides. Antibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesAbe, T., et al. 2003. Neurosci. Lett. 336, 105.
      Parker, A.R., et al. 2002. Cancer Res. 62, 7230.
      Citation
    • Barouch, L.A., et al. 2006. Circulation Research 98, 119.
      		•
      Application referencesParaffin Sections Barouch, L.A., et al. 2006. Circ. Res. 98, 119.