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PC552 Anti-ACINUS (Ab-2) (1329-1341) Rabbit pAb

Anti-ACINUS (Ab-2) (1329-1341) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
PC552
  
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      Overview

      Replacement Information

      Key Spec Table

      Host
      Rb
      Description
      Overview

      This product has been discontinued.





      Recognizes the ~220 kDa AcinusL protein in K562 cells.
      Catalogue NumberPC552
      Brand Family Calbiochem®
      Application Data
      Detection of human Acinus by immunoblotting. Sample: Whole cell lysate from K562 cells. Primary antibody: Anti-ACINUS (Ab-2) (1329-1341) Rabbit pAb (Cat. No. PC552) (0.5 µg/ml). Detection: chemiluminescence.
      References
      ReferencesSahara, S., et al. 1999. Nature 401, 168.
      Zamzami, N. and Kroemer G. 1999. Nature 401, 127.
      Product Information
      FormLiquid
      FormulationIn PBS.
      Positive controlK562 cells
      Preservative≤0.1% sodium azide
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Application NotesImmunoblotting (0.25-0.5 µg/ml)
      Application CommentsAntibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide (SRSTPVRDRGGRR) corresponding to amino acids 1329-1341 of human Acinus
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      PC552 0

      Documentation

      References

      Reference overview
      Sahara, S., et al. 1999. Nature 401, 168.
      Zamzami, N. and Kroemer G. 1999. Nature 401, 127.

      Brochure

      Title
      Antibody Sourcebookﾙ Sixth Edition
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-October-2007 RFH
      ApplicationImmunoblotting (0.25-0.5 µg/ml)
      Application Data
      Detection of human Acinus by immunoblotting. Sample: Whole cell lysate from K562 cells. Primary antibody: Anti-ACINUS (Ab-2) (1329-1341) Rabbit pAb (Cat. No. PC552) (0.5 µg/ml). Detection: chemiluminescence.
      DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the ~220 kDa AcinusL protein.
      BackgroundChromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of the caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus, a ~220 kDa protein, is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide (SRSTPVRDRGGRR) corresponding to amino acids 1329-1341 of human Acinus
      IsotypeIgG
      Specieshuman
      Positive controlK562 cells
      FormLiquid
      FormulationIn PBS.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsAntibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesSahara, S., et al. 1999. Nature 401, 168.
      Zamzami, N. and Kroemer G. 1999. Nature 401, 127.