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PC538 Anti-ATR (Ab-2) (2122-2644) Rabbit pAb

Anti-ATR (Ab-2) (2122-2644), rabbit polyclonal, recognizes the ~300 kDa ATR protein in human and in mouse testis tissue extracts. It is validated for Western blotting.

Anti-ATR (Ab-2) (2122-2644) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-Ataxia telangicctasia and Rad3 related protein

PC538
  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityHostAntibody Type
      Ht, H, MRbPolyclonal Antibody
      Description
      Overview

      This product has been discontinued.




      Recognizes the ~300 kDa ATR protein in human and mouse testis tissue extracts.
      Catalogue NumberPC538
      Brand Family Calbiochem®
      SynonymsAnti-Ataxia telangicctasia and Rad3 related protein
      References
      ReferencesCliby, W.A., et al. 1998. EMBO J. 17, 159.
      Sarkaria, J.N., et al. 1998. Submitted
      Bentley, N.J., et al. 1996. EMBO J. 15, 6641.
      Cimprich, K.A., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2850.
      Elledge, S.J. 1996. Science 274, 1664.
      Keegan, K.S., et al. 1996. Genes Dev. 10, 2423.
      Keith C.T. and Schreiber, S.L. 1995. Science 270, 50.
      Paules, R.S., et al. 1995. Cancer Res. 55, 1763.
      Hartwell, L.H. and Kastan, M. 1994. Science 266, 1821.
      Product Information
      FormLiquid
      FormulationUndiluted serum.
      Positive controlHuman or mouse testis tissue
      Preservative≤0.1% sodium azide
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Application NotesImmunoblotting (1:2000)
      Application CommentsAntibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide corresponding to amino acids 2122-2644 of human ataxia telangiectasia and Rad 3-related (ATR) protein
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Hamster
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      PC538 0

      Documentation

      Anti-ATR (Ab-2) (2122-2644) Rabbit pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-ATR (Ab-2) (2122-2644) Rabbit pAb Certificates of Analysis

      TitleLot Number
      PC538

      References

      Reference overview
      Cliby, W.A., et al. 1998. EMBO J. 17, 159.
      Sarkaria, J.N., et al. 1998. Submitted
      Bentley, N.J., et al. 1996. EMBO J. 15, 6641.
      Cimprich, K.A., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2850.
      Elledge, S.J. 1996. Science 274, 1664.
      Keegan, K.S., et al. 1996. Genes Dev. 10, 2423.
      Keith C.T. and Schreiber, S.L. 1995. Science 270, 50.
      Paules, R.S., et al. 1995. Cancer Res. 55, 1763.
      Hartwell, L.H. and Kastan, M. 1994. Science 266, 1821.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-October-2007 RFH
      SynonymsAnti-Ataxia telangicctasia and Rad3 related protein
      ApplicationImmunoblotting (1:2000)
      DescriptionRabbit polyclonal antibody supplied as undiluted serum. Recognizes the ~300 kDa ATR protein.
      BackgroundEukaryotic cells arrest growth at discrete stages in the cell cycle called checkpoints in order to repair/replace damaged DNA. Checkpoints are also essential for orderly progression and completion of DNA replication and chromosome segregation. Failure to execute a checkpoint can lead to genomic instability and subsequent tumor development. All eukaryotic organisms contain multiple genes required for executing DNA damage checkpoints. The human ATR/FRP1 gene, initially identified on the basis of its sequence similarity to the human FRAP/mTOR, S. cerevisiae MEC1/ESR, S. pombe Rad3, and D. melanogaster Mei-41 genes, encodes a serine/threonine kinase involved in DNA damage response pathways. ATR is also member of a growing family of phosphatidylinositol kinase-related (PIK-R) genes, characterized by their large size and encoding proteins greater than 200 kDa; additional PIK-R genes include the ATM gene (Ataxia-Telangiectasia Mutated) and the catalytic subunit of DNA-PK (DNA dependent protein kinase). Introduction of human ATR into mec1 mutants S. cerevisiae corrects some but not all of the mec1 defects. ATR may also be critical for meiotic checkpoints since the protein binds unsynapsed chromosomes. Recent work confirms a role for ATR in the DNA damage G2/M checkpoint since human cells over-expressing a mutant ATR exhibit increased sensitivity to DNA damaging agents and are unable to arrest at the G2/M checkpoint. The PIK-R kinases can be inhibited by wortmannin, a known radiosensitizer, although ATR is less sensitive to Wortmannin (Cat. No. 681675) than the ATM and DNA-PK kinases.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide corresponding to amino acids 2122-2644 of human ataxia telangiectasia and Rad 3-related (ATR) protein
      IsotypeIgG
      Specieshamster, human, mouse
      Positive controlHuman or mouse testis tissue
      FormLiquid
      FormulationUndiluted serum.
      Preservative≤0.1% sodium azide
      CommentsAntibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesCliby, W.A., et al. 1998. EMBO J. 17, 159.
      Sarkaria, J.N., et al. 1998. Submitted
      Bentley, N.J., et al. 1996. EMBO J. 15, 6641.
      Cimprich, K.A., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2850.
      Elledge, S.J. 1996. Science 274, 1664.
      Keegan, K.S., et al. 1996. Genes Dev. 10, 2423.
      Keith C.T. and Schreiber, S.L. 1995. Science 270, 50.
      Paules, R.S., et al. 1995. Cancer Res. 55, 1763.
      Hartwell, L.H. and Kastan, M. 1994. Science 266, 1821.