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MABC613 Anti-B7-H6 Antibody, clone 5.51.18

Anti-B7-H6 Antibody, clone 5.51.18 is an antibody against B7-H6 for use in Flow Cytometry.

Anti-B7-H6 Antibody, clone 5.51.18 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: NCR3LG1, B7H6 UniProt Number: Q68D85
MABC613
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC613
      DescriptionAnti-B7-H6 Antibody, clone 5.51.18
      Alternate Names
      • B7-H6
      • Natural cytotoxicity triggering receptor 3 ligand 1
      • B7 homolog 6
      Background InformationB7-H6 (also known as B7 homolog 6 or Natural cytotoxicity triggering receptor 3 ligand 1) is a single-pass membrane protein encoded by the NCR3LG1 or B7H6 gene (Entrez Gene ID 374383) in human. B7-H6 belongs to the B7 family of structurally related cell-surface ligands, which bind to receptors on lymphocytes that regulate immune responses. The natural cytotoxicity receptor NCR3/NKp30 is involved in NK-cell–mediated killing of various tumor cell lines. B7-H6 is identified as the NKp30 ligand on cancer cells, while normal tissues were reported to lack B7-H6 transcripts. Decreased NKp30 expression is reported to correlate with poor prognosis and survival among patients with acute myeloid leukemia (AML). Class I histone deacetylases HDAC2 & HDAC3 are reported to be involved in B7-H6 transcription activation, and HDAC inhibitors are found to impair tumor cell recognition by NK cells. This monoclonal antibody is suitable for flow cytometric analysis, but does not compete against NKp30 binding (PMID 23801635).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationAnti-B7-H6 Antibody, clone 5.51.18 is an antibody against B7-H6 for use in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 20 µg of this antibody from a representative lot detected B7-H6 in cervix carcinom HeLa
      cells (Dr. Adelheid Cerwenka, DKFZ).
      Biological Information
      ImmunogenRecombinant protein corresponding to the extracellular domain of human B7-H6.
      Epitopeextracellular domain
      Clone5.51.18
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NCR3LG1
      • B7H6
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight51 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in BA/F6-B7-H6 cells.

      Flow Cytometry Analysis: 0.5 µg of this antibody detected B7-H6 in BA/F3 B7-H6 cells .
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC613 04055977164060