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MABS518 Anti-CBS Antibody, clone 9F3.2

Anti-CBS Antibody, clone 9F3.2 is an antibody against CBS for use in Western Blotting, Immunohistochemistry (Paraffin).

Anti-CBS Antibody, clone 9F3.2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: CBS UniProt Number: P35520
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MABS518
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS518
      DescriptionAnti-CBS Antibody, clone 9F3.2
      Alternate Names
      • Cystathionine beta-synthase
      • CBS
      • Beta-thionase
      • Serine sulfhydrase
      Background InformationCystathionine beta-synthase (EC 4.2.1.22; UniProt P35520; also known as beta-thionase, Methylcysteine synthase, Serine sulfhydrase) is encoded by the CBS (also known as HIP4) gene (Gene ID 875) in human. Cystathionine beta-synthase catalyzes the trans-sulfuration of homocysteine and serine to form the cysteine precursor cystathionine in the folate pathway. Cysteine is an essential substrate for the biosynthesis of glutathione, a major endogenous antioxidant. CBS deficiency results in altered sulfur metabolism and homocystinuria characterized by increased urinary homocystine and methionine. The clinical features of untreated homocystinuria due to CBS deficiency include myopia, ectopia lentis, mental retardation, skeletal anomalies resembling Marfan syndrome, and thromboembolic events.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CBS Antibody, clone 9F3.2 is an antibody against CBS for use in Western Blotting, Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected CBS in human liver and human pancreas tissue.
      Biological Information
      ImmunogenRecombinant protein corresponding to the N-terminal of human CBS.
      EpitopeN-terminal
      Clone9F3.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityExpected to react with both the Major (isoform 1) and the Minor (isoform 2) spliced variant.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CBS
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~61 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Raji cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected CBS in 10 µg of Raji cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS518 04055977182828

      Documentation

      Anti-CBS Antibody, clone 9F3.2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-CBS Antibody, clone 9F3.2 Certificates of Analysis

      TitleLot Number
      Anti-CBS, clone 9F3.2 - 3384388 3384388
      Anti-CBS, clone 9F3.2 - 4113023 4113023
      Anti-CBS, clone 9F3.2 -Q2589906 Q2589906

      Brochure

      Title
      New Products Flyer- Vol 4 Signaling Feature- NEW! Phosphohistidine Antibody

      Technical Info

      Title
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      White Paper: Further considerations of antibody validation and usage.

      Posters

      Title
      Post-Translational Modifications