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MABF913 Anti-CD37 Antibody, clone MB-1

Anti-CD37 Antibody, clone MB-1 is an antibody against CD37 for use in Flow Cytometry, Immunohistochemistry, Immunoprecipitation.

Anti-CD37 Antibody, clone MB-1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunological Signaling Gene Symbol: CD37, TSPAN26 UniProt Number: P11049
MABF913
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, IHC, IPMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF913
      DescriptionAnti-CD37 Antibody, clone MB-1
      Alternate Names
      • Leukocyte antigen CD37
      • CD37
      • Tetraspanin-26
      • Tspan-26
      Background InformationLeukocyte antigen CD37 (UniProt P11049; also known as CD37, Tetraspanin-26, Tspan-26) is encoded by the CD37 (also known as TSPAN26) gene (Gene ID 951) in human. CD37 is a 4-transmembrane (a.a. 18-38, 60-74, 86-111, 242-266) tetraspanin superfamily member with both its N- and C-terminal ends exposed cytoplasmically (a.a. 1-17, 267-281). While most tetraspanins are ubiquitously expressed, CD37 is predominently expressed on antigen-presenting cells, with highest expression on B lymphocytes. CD37 is essential for B cell survival and Cd37-/- mice showed greatly reduced IgG-secreting plasma cells in lymphoid organs due to increased apoptosis in the spleen germinal centers, where B cells proliferate. On the other hand, CD37 is also found to play a negative role against T cell proliferation, macrophages interleukin-6 production, and dendritic cells (DCs) antigen presentation.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CD37 Antibody, clone MB-1 is an antibody against CD37 for use in Flow Cytometry, Immunohistochemistry, Immunoprecipitation.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry
      • Immunoprecipitation
      Application NotesFlow Cytometry Analysis: A representative lot immunostained the B cell population in isolated normal human tonsil cells (Link, M.P., et al. (1986). J. Immunol. 137(9):3013-3018).
      Immunohistochemistry Analysis: A representative lot detected MB-1 antigen-expressing B cells in acetone-fixed frozen normal human tonsil sections as well as lymph node sections from a patient with follicular small cleaved cell lymphoma (Link, M.P., et al. (1986). J. Immunol. 137(9):3013-3018).
      Immunoprecipitation Analysis: A representative lot immunoprecipitated the 42 kDa CD37 from a Prolymphocytic Leukemia (PLL) patient-derived tumor cell lysates (Link, M.P., et al. (1986). J. Immunol. 137(9):3013-3018).
      Biological Information
      ImmunogenLymph node cells from a lymphoma patient.
      EpitopeExtracellular domain.
      CloneMB-1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityMB-1 antigen is found on all normal immunoglobulin (Ig)-expressing cells, but not on T cells, thymocytes, granulocytes, or platelets. MB-1 antigen is expressed late in B cell ontogeny before the expression of SIg (Link, M.P., et al. (1986). J. Immunol. 137(9):3013-3018).
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CD37
      • TSPAN26
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight31.70 kDa calculated. ~42 kDa reported (Link, M.P., et al. (1986). J. Immunol. 137(9):3013-3018) due to glycosylation.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in human PBMCs.

      Flow Cytometry Analysis: 0.1 µg of this antibody immunostained CD37 on the surface of one million human PBMCs.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF913 04055977333633