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ST1682 Anti-COPS2 Mouse mAb (4B12)

This Anti-COPS2 Mouse mAb (4B12) is validated for use in Immunoblotting for the detection of COPS2.

Anti-COPS2 Mouse mAb (4B12) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-COP9 Singlasome Complex Subunit 2

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ST1682
  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityHostAntibody Type
      HMMonoclonal Antibody
      Description
      OverviewRecognizes the ~50 kDa COPS2 protein in PC-12, HeLe NE,and Raw 264.7 cells.
      Catalogue NumberST1682
      Brand Family Calbiochem®
      SynonymsAnti-COP9 Singlasome Complex Subunit 2
      Application Data
      Detection of rat COPS2 by immunoblotting. Sample: Whole cell lysate from PC-12 cells. Primary antibody: Anti-COPS2 Mouse mAb (4B12) (Cat. No. ST1682) (1-5 µg/ml). Detection: chemiluminescence.

      Detection of human COPS2 by immunoblotting. Sample: Whole cell lysate from HeLa NE cells. Primary antibody: Anti-COPS2 Mouse mAb (4B12) (Cat. No. ST1682) (1-5 µg/ml). Detection: chemiluminescence.

      Detection of mouse COPS2 by immunoblotting. Sample: Whole cell lysate from Raw 264.7 cells. Primary antibody: Anti-COPS2 Mouse mAb (4B12) (Cat. No. ST1682) (1-5 µg/ml). Detection: chemiluminescence.
      References
      Product Information
      FormLiquid
      FormulationIn PBS, pH 7.2.
      Positive controlPC-12 cells, HeLe NE cells, Raw 264.7 cells
      PreservativeNone
      Quality LevelMQ100
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Application NotesImmunoblotting (1-5 µg/ml)
      Application CommentsVariables associated with assay conditions will dictate the proper working dilution.
      Biological Information
      ImmunogenA recombinant polypeptide corresponding to amino acids of 344-444 human COPS2, expressed as a GST fusion protein
      Clone4B12
      HostMouse
      IsotypeIgG2a
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Regulatory Review
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ST1682 0

      Documentation

      Anti-COPS2 Mouse mAb (4B12) SDS

      Title

      Safety Data Sheet (SDS) 

      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-November-2010 RFH
      SynonymsAnti-COP9 Singlasome Complex Subunit 2
      ApplicationImmunoblotting (1-5 µg/ml)
      Application Data
      Detection of rat COPS2 by immunoblotting. Sample: Whole cell lysate from PC-12 cells. Primary antibody: Anti-COPS2 Mouse mAb (4B12) (Cat. No. ST1682) (1-5 µg/ml). Detection: chemiluminescence.

      Detection of human COPS2 by immunoblotting. Sample: Whole cell lysate from HeLa NE cells. Primary antibody: Anti-COPS2 Mouse mAb (4B12) (Cat. No. ST1682) (1-5 µg/ml). Detection: chemiluminescence.

      Detection of mouse COPS2 by immunoblotting. Sample: Whole cell lysate from Raw 264.7 cells. Primary antibody: Anti-COPS2 Mouse mAb (4B12) (Cat. No. ST1682) (1-5 µg/ml). Detection: chemiluminescence.
      DescriptionPurified mouse monoclonal antibody. Recognizes the ~50 kDa COPS2 protein.
      BackgroundThe COPS2 protein is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. It is involved in early stage of neuronal differentiation via its interaction with NIF3L1.
      HostMouse
      ImmunogenA recombinant polypeptide corresponding to amino acids of 344-444 human COPS2, expressed as a GST fusion protein
      Clone4B12
      IsotypeIgG2a
      Specieshuman
      Positive controlPC-12 cells, HeLe NE cells, Raw 264.7 cells
      FormLiquid
      FormulationIn PBS, pH 7.2.
      PreservativeNone
      CommentsVariables associated with assay conditions will dictate the proper working dilution.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Regulatory Review