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ST1043 Anti-CSN3 Rabbit pAb

Anti-CSN3 Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-COP9 Signalosome Complex Subunit 3

ST1043
  
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      Overview

      Replacement Information

      Key Spec Table

      Host
      Rb
      Description
      Overview

      This product has been discontinued.





      Recognizes the ~40 kDa CSN3 protein in HEK293 cells.
      Catalogue NumberST1043
      Brand Family Calbiochem®
      SynonymsAnti-COP9 Signalosome Complex Subunit 3
      Application Data
      Detection of human CSN3 by immunoblotting. Samples: whole cell lysate from HEK293 cells mock transfected (E, 50 µg) and transfected with CNS3 expression construct (T, 25 micro;g). Primary antibody: Anti-CSN3 Rabbit pAb (Cat. N0. ST1043) (0.2 µg/ml, 0.1 µg/ml, and 40 ng/ml, as indicated). Detection: chemiluminescence.
      References
      ReferencesWei, N. and Deng, X.W. 2003. Annu. Rev. Cell Dev. Biol. 19, 261.
      Yan, J., et al. 2003. Mol. Cell. Biol. 23, 6798.
      Hong, X., et al. 2001. FEBS Lett. 499, 133.
      Product Information
      FormLiquid
      FormulationIn Tris-citrate/phosphate buffer, pH 7.0-8.0.
      Positive controlHEK293 cells
      Preservative≤0.1% sodium azide
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Application NotesImmunoblotting (1:5000-1:25,000)
      Application CommentsDetects both endogenous (eCSN3) and recombinant (rCSN3) (see application data). Antibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide corresponding to amino acids encoded within exon 10 of human CSN3
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Highly Toxic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFor long-term storage aliquot and freeze (-20°C). Avoid freeze/thaw cycles.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ST1043 0

      Documentation

      Anti-CSN3 Rabbit pAb Certificates of Analysis

      TitleLot Number
      ST1043

      References

      Reference overview
      Wei, N. and Deng, X.W. 2003. Annu. Rev. Cell Dev. Biol. 19, 261.
      Yan, J., et al. 2003. Mol. Cell. Biol. 23, 6798.
      Hong, X., et al. 2001. FEBS Lett. 499, 133.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-October-2007 RFH
      SynonymsAnti-COP9 Signalosome Complex Subunit 3
      ApplicationImmunoblotting (1:5000-1:25,000)
      Application Data
      Detection of human CSN3 by immunoblotting. Samples: whole cell lysate from HEK293 cells mock transfected (E, 50 µg) and transfected with CNS3 expression construct (T, 25 micro;g). Primary antibody: Anti-CSN3 Rabbit pAb (Cat. N0. ST1043) (0.2 µg/ml, 0.1 µg/ml, and 40 ng/ml, as indicated). Detection: chemiluminescence.
      DescriptionImmunoaffinity purified rabbit polyclonal antibody. Detects the ~40 kDa CSN3 protein.
      BackgroundThe COP9 signalosome (CSN) is composed of eight distinct subunits and is highly homologous to the lid subcomplex of the 26S proteasome. CSN is associated with de-ubiquitination activity and protein kinase activities capable of phosphorylating important signaling regulators. CSN is involved in a number of cellular and developmental processes. It has been reported that CSN3 inhibits the NF-κB activation triggered by tumor necrosis factor (TNF) but not that triggered by IL-1.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide corresponding to amino acids encoded within exon 10 of human CSN3
      IsotypeIgG
      Specieshuman
      Positive controlHEK293 cells
      FormLiquid
      FormulationIn Tris-citrate/phosphate buffer, pH 7.0-8.0.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsDetects both endogenous (eCSN3) and recombinant (rCSN3) (see application data). Antibody should be titrated for optimal results in individual systems.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFor long-term storage aliquot and freeze (-20°C). Avoid freeze/thaw cycles.
      Toxicity Highly Toxic
      ReferencesWei, N. and Deng, X.W. 2003. Annu. Rev. Cell Dev. Biol. 19, 261.
      Yan, J., et al. 2003. Mol. Cell. Biol. 23, 6798.
      Hong, X., et al. 2001. FEBS Lett. 499, 133.