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AB10088 Anti-CYP450 1A1 Antibody

This Anti-CYP450 1A1 Antibody is validated for use in WB for the detection of CYP450 1A1.

Anti-CYP450 1A1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Metabolism Research Sub-Category: Enzymes & Biochemistry Gene Symbol: CYP1A1, CP11, P1-450, CYPIA1, P450-C, CYP1, P450DX, P450-P1, AHRR, AHH UniProt Number: P04798
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AB10088
50 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB10088
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CYP450 1A1 Antibody
      Alternate Names
      • Cytochrome P450
      References
      Product Information
      FormatSerum
      PresentationRaw Rabbit Serum with 0.1% Sodium Azide
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-CYP450 1A1 Antibody is validated for use in WB for the detection of CYP450 1A1.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenRecombinant CYP450 1A1
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
      Gene Symbol
      • CYP1A1
      • CP11
      • P1-450
      • CYPIA1
      • P450-C
      • CYP1
      • P450DX
      • P450-P1
      • AHRR
      • AHH
      Purification MethodSerum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P04798 # Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
      SIZE: 512 amino acids; 58165 Da
      SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
      TISSUE SPECIFICITY: Lung, lymphocytes and placenta.
      SIMILARITY: SwissProt: P04798 ## Belongs to the cytochrome P450 family.
      Molecular Weight58 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at 2-8°C from date of shipment
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB10088 04053252581335

      Documentation

      Anti-CYP450 1A1 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overviewPub Med ID
      Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers
      Smith, Cornelia M, et al
      J Biochem Mol Toxicol, 19:96-108 ()  2005

      		15849716 15849716
      Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo
      Thapliyal, R and Maru, G B
      Food Chem Toxicol, 39:541-7 (2001)  2001

      		11346483 11346483

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies