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AB5630P Anti-Ca++ Sensing Receptor Antibody

This Anti-Ca++ Sensing Receptor Antibody is validated for use in ELISA, WB for the detection of Ca++ Sensing Receptor.

Anti-Ca++ Sensing Receptor Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Signaling Neuroscience, Neurotransmitters & Receptors Gene Symbol: CASR, PCAR1, CAR, MGC138441, FIH, HHC1, NSHPT, HHC, GPRC2A, FHH, CaSR UniProt Number: P41180
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AB5630P
50 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5630P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Ca++ Sensing Receptor Antibody
      Alternate Names
      • CaSR
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Ca++ Sensing Receptor Antibody is validated for use in ELISA, WB for the detection of Ca++ Sensing Receptor.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1-10 μg/mL using ECL.

      ELISA: 0.5-1 μg/mL using 1 μg/mL control peptide (Cat. No. AG359) per well.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenA 20 amino acid peptide sequence near the C-terminus of human CaSR. The immunogen sequence is 90% conserved in rat/mouse and 85% in bovine.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Calcium Sensing Receptor (CaSR).
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe calcium-sensing receptor (CASR) functions as a sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, whereas mutations that activate CASR are the cause of autosomal dominant hypocalcemia. An altenatively spliced transcript variant encoding 1088 aa has been found for this gene, but its full-length nature has not been defined.
      Gene Symbol
      • CASR
      • PCAR1
      • CAR
      • MGC138441
      • FIH
      • HHC1
      • NSHPT
      • HHC
      • GPRC2A
      • FHH
      • CaSR
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P41180 # Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.
      SIZE: 1078 amino acids; 120674 Da
      SUBUNIT: Interacts with VCP and RNF19A.
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Found in kidney, but not in brain, lung, liver, heart, skeletal muscle, or placenta.
      PTM: N-glycosylated. & Ubiquitinated by RNF19A; which induces proteasomal degradation.
      DISEASE: SwissProt: P41180 # Defects in CASR are the cause of familial hypocalciuric hypercalcemia type 1 (FHH) [MIM:145980]; in which the receptor has reduced activity. FHH is characterized by altered calcium homeostasis. Affected individuals exhibit mild or modest hypercalcemia, relative hypocalciuria, and inappropriately normal PTH levels. & Defects in CASR are the cause of neonatal severe primary hyperparathyroidism (NSHPT) [MIM:239200]; in which the receptor has reduced activity. NSHPT is a rare autosomal recessive life- threatening disorder characterized by very high serum calcium concentrations, skeletal demineralization, and parathyroid hyperplasia. In some instances NSHPT has been demonstrated to be the homozygous form of FHH. & Defects in CASR are the cause of autosomal dominant hypoparathyroidism (FIH) [MIM:146200]. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps.
      SIMILARITY: SwissProt: P41180 ## Belongs to the G-protein coupled receptor 3 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5630P 04053252729973