219384 Anti-Cathepsin S Rabbit pAb

219384
  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityHostAntibody Type
      HRbPolyclonal Antibody
      Description
      Overview

      This product has been discontinued.



      Recognizes the ~37 kDa latent and the ~28 kDa active forms of cathepsin S in human tumors.

      Catalogue Number219384
      Brand Family Calbiochem®
      References
      ReferencesShi, Guo-Ping, et al. 1992. J. Biol. Chem. 267, 7258.
      Wiederanders, B. et al. 1992. J. Biol. Chem. 269, 13708.
      Chauhan, S.S., et al. 1991. Cancer Res. 51, 1487.
      Kane, S.E. and Gottesman, M.M. 1990. In Seminars in Cancer Biology, ed, M.M. Gottesman, Vol 1; 137-152.
      Barrett, A., et al. 1981. Meth. Enzymol. 80, 535.
      Kane, S.E. and Gottesman, M.M. 1990. In Seminars in Cancer Biology, ed., M.M. Gottesman, Vol1; 137-152.
      Chauhan, S.S., et al. 1991. Cancer Res. 51, 1487.
      Product Information
      FormLiquid
      FormulationUndiluted serum.
      Preservative≤0.1% sodium azide
      Quality LevelMQ100
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Application NotesImmunoblotting (1:1000-1:2000, colorimetric)
      Application CommentsVariables associated with assay conditions will dictate the optimal working dilution.
      Biological Information
      Immunogenrecombinant, human cathepsin S fused to maltose binding protein and expressed in E. coli
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Cathepsin S Rabbit pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Cathepsin S Rabbit pAb Certificates of Analysis

      TitleLot Number
      219384

      References

      Reference overview
      Shi, Guo-Ping, et al. 1992. J. Biol. Chem. 267, 7258.
      Wiederanders, B. et al. 1992. J. Biol. Chem. 269, 13708.
      Chauhan, S.S., et al. 1991. Cancer Res. 51, 1487.
      Kane, S.E. and Gottesman, M.M. 1990. In Seminars in Cancer Biology, ed, M.M. Gottesman, Vol 1; 137-152.
      Barrett, A., et al. 1981. Meth. Enzymol. 80, 535.
      Kane, S.E. and Gottesman, M.M. 1990. In Seminars in Cancer Biology, ed., M.M. Gottesman, Vol1; 137-152.
      Chauhan, S.S., et al. 1991. Cancer Res. 51, 1487.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-July-2007 RFH
      ApplicationImmunoblotting (1:1000-1:2000, colorimetric)
      DescriptionRabbit polyclonal antibody supplied as undiluted serum. Recognizes the ~37 kDa latent and the ~28 kDa active forms of cathepsin S.
      BackgroundCathepsin S is a cysteine proteinase expressed in a variety of cells. The latent pro-cathepsin S (37 kDa) is processed to the active single chain form (28 kDa). Unlike cathepsin B and cathepsin L, cathepsin S exists only in single chain form. The pro peptide contains 99 amino acids. Mature Cathepsin S is normally localized in the lysosomes where it plays a major role in intracellular protein catabolism. High levels of cathepsin S expression have been demonstrated for many human tumors including cancers of the kidney, lung, colon, breast and ovary.
      HostRabbit
      Immunogen speciesHuman
      Immunogenrecombinant, human cathepsin S fused to maltose binding protein and expressed in E. coli
      IsotypeIgG
      Specieshuman
      FormLiquid
      FormulationUndiluted serum.
      Preservative≤0.1% sodium azide
      CommentsVariables associated with assay conditions will dictate the optimal working dilution.
      Storage -20°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesShi, Guo-Ping, et al. 1992. J. Biol. Chem. 267, 7258.
      Wiederanders, B. et al. 1992. J. Biol. Chem. 269, 13708.
      Chauhan, S.S., et al. 1991. Cancer Res. 51, 1487.
      Kane, S.E. and Gottesman, M.M. 1990. In Seminars in Cancer Biology, ed, M.M. Gottesman, Vol 1; 137-152.
      Barrett, A., et al. 1981. Meth. Enzymol. 80, 535.
      Kane, S.E. and Gottesman, M.M. 1990. In Seminars in Cancer Biology, ed., M.M. Gottesman, Vol1; 137-152.
      Chauhan, S.S., et al. 1991. Cancer Res. 51, 1487.