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PK1017 Anti-Corin Rabbit pAb

Anti-Corin Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-CRN Rabbit pAb, Anti-TMPRSS10 Rabbit pAb, Anti-Lrp4 Rabbit pAb, Anti-ATC2 Rabbit pAb

PK1017
  
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      Overview

      Replacement Information

      Key Spec Table

      Host
      Rb
      Description
      Overview

      This product has been discontinued.





      Recognizes the ~150 kDa corin protein in HepG2 cells.
      Catalogue NumberPK1017
      Brand Family Calbiochem®
      SynonymsAnti-CRN Rabbit pAb, Anti-TMPRSS10 Rabbit pAb, Anti-Lrp4 Rabbit pAb, Anti-ATC2 Rabbit pAb
      Application Data
      Lane 1: Detection of human corin by immunoblotting. Sample: Whole cell lysate (40 µg) from HepG2 cells. Primary antibody: Anti-Corin Rabbit pAb (Cat. No. PK1017) (0.03 µg/ml). Detection: chemiluminescence. Lane 2: Detection of human corin by immunoprecipitation followed by immunoblotting. Sample: Whole cell lysate from HepG2 cells. Immunoblotting conditions: Sample: one-fourth of the corin IP per lane. Primary antibody and Detection: same as above.
      References
      ReferencesBurnett, J. and Olson, T.M. 2007. Hypertension 49, 765.
      Wu, Q. 2007. Front Biosci. 12, 4179.
      Wu, Q., et al. 2005. Biochim. Biophys. Acta 1751, 82.
      Product Information
      FormLiquid
      FormulationIn Tris/citrate/phosphate buffer, pH 7-8.
      Positive controlHepG2 cells
      Preservative≤0.1% sodium azide
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Immunoprecipitation
      Application NotesImmunoblotting (0.03 µg/ml)
      Immunoprecipitation (10 µg/mg total protein)
      Application CommentsAntibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide corresponding to amino acids from the N-terminus of human corin.
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      PK1017 0

      Documentation

      References

      Reference overview
      Burnett, J. and Olson, T.M. 2007. Hypertension 49, 765.
      Wu, Q. 2007. Front Biosci. 12, 4179.
      Wu, Q., et al. 2005. Biochim. Biophys. Acta 1751, 82.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-January-2008 JSW
      SynonymsAnti-CRN Rabbit pAb, Anti-TMPRSS10 Rabbit pAb, Anti-Lrp4 Rabbit pAb, Anti-ATC2 Rabbit pAb
      ApplicationImmunoblotting (0.03 µg/ml)
      Immunoprecipitation (10 µg/mg total protein)
      Application Data
      Lane 1: Detection of human corin by immunoblotting. Sample: Whole cell lysate (40 µg) from HepG2 cells. Primary antibody: Anti-Corin Rabbit pAb (Cat. No. PK1017) (0.03 µg/ml). Detection: chemiluminescence. Lane 2: Detection of human corin by immunoprecipitation followed by immunoblotting. Sample: Whole cell lysate from HepG2 cells. Immunoblotting conditions: Sample: one-fourth of the corin IP per lane. Primary antibody and Detection: same as above.
      DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the ~150 kDa corin protein.
      BackgroundCorin (Acc # NM-006587) is a 150 kDa protein and a member of the type II transmembrane serine protease family. The members of this protease family are grouped into four subfamilies consisting of hepsin/transmemebrane protease, serine (TMPRSS); matriptase; corin; and the human airway trypsin (HAT)/DESC subfamilies. Among these proteases, corin is the only one highly expressed in the heart where it plays a critical role in maintaining blood pressure. Corin has been identified as the atrial natriuretic peptide (ANP) convertase. ANP is a 151 amino acid prepropeptide expressed in cardiomyocytes. Upon stimulation during high blood pressure, pro-ANP is proteolytically converted by corin to active ANP and released into the circulation. ANP activates its cell surface receptor and causes an increase of cellular cGMP concentration, which results in a lowering of blood pressure. Recently, single nucleotide polymorphisms have been identified in the human corin gene, which are associated with increased risk of hypertension and cardiac hypertrophy.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide corresponding to amino acids from the N-terminus of human corin.
      IsotypeIgG
      Specieshuman
      Positive controlHepG2 cells
      FormLiquid
      FormulationIn Tris/citrate/phosphate buffer, pH 7-8.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsAntibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesBurnett, J. and Olson, T.M. 2007. Hypertension 49, 765.
      Wu, Q. 2007. Front Biosci. 12, 4179.
      Wu, Q., et al. 2005. Biochim. Biophys. Acta 1751, 82.