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06-1287 Anti-DAI Antibody

Detect DAI using this Anti-DAI Antibody validated for use in WB.

Research Category: Inflammation & Immunology Research Sub-Category: Immunological Signaling Gene Symbol: DLM1, DLM-1, DAI, ZBP1 UniProt Number: Q9QY24
06-1287
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1287
      DescriptionAnti-DAI Antibody
      Alternate Names
      • Z-DNA binding protein 1
      • chromosome 20 open reading frame 183
      • DNA-dependent activator of IRFs
      • DNA-dependent activator of interferon regulatory factors
      • Tumor stroma and activated macrophage protein DLM-1
      Background InformationDNA-dependent activator of IFN regulatory factors (DAI), also known as DLM-1/ZBP1, belongs to the Zipcode-binding protein (ZBP) family. This family of proteins regulate the stability and localization of their target mRNA. It is expressed during embryonic development, but repressed in normal adult tissue. When re-activated, it has been detected in tumors such as breast, colon, and non-small cell carcinomas.
      References
      Product Information
      FormatPurified
      Control
      • LPS-treated (positive control) and untreated (negative control) RAW264.7 cell lysate
      PresentationPurified rabbit polyclonal in PBS with 0.05% sodium azide.
      Applications
      ApplicationDetect DAI using this Anti-DAI Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenRecombinant protein corresponding to mouse DAI.
      EpitopeUnknown
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes DAI.
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • DLM1
      • DLM-1
      • DAI
      • ZBP1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: May play a role in host defense against tumors and pathogens. Binds Z-DNA.

      TISSUE SPECIFICITY: Expressed in lung, spleen and liver. Lower levels were seen in heart, kidney and testis. Expression is greatly up-regulated in tumor stromal cells and activated macrophages.

      INDUCTION: By interferon gamma and lipopolysaccharides (LPS).

      SEQUENCE SIMLARITIES: Contains 2 DRADA repeats.
      Molecular Weight~55 kDa observed.
      A non-specific bands may be observed at ~70 & 35 kDa (Karayel, E., et al. (2009). Eur. J. Immunol. 39:1–8).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in LPS untreated and treated RAW264.7 cell lysate.

      Western Blot Analysis: A 1:1,000 dilution of this antibody was used in 10 µg of LPS-treated (positive control) and untreated (negative control) RAW264.7 cell lysate for the purpose of detecting DAI.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      06-1287 04053252628825

      Documentation