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ABE1028 Anti-E3 ubiquitin-protein ligase UHRF2 Antibody

Anti-E3 ubiquitin-protein ligase UHRF2 Antibody is an antibody against E3 ubiquitin-protein ligase UHRF2 for use in Immunohistochemistry and Immunocytochemistry.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: UHRF2, NIRF, RNF107 UniProt Number: Q96PU4
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ABE1028
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1028
      DescriptionAnti-E3 ubiquitin-protein ligase UHRF2 Antibody
      Alternate Names
      • E3 ubiquitin-protein ligase UHRF2
      • Np95/ICBP90-like RING finger protein
      • Np95-like RING finger protein
      • Nuclear protein 97
      • Nuclear zinc finger protein Np97
      • RING finger protein 107
      • Ubiquitin-like PHD and RING finger domain-containing protein 2
      • Ubiquitin-like-containing PHD and RING finger domains protein 2
      • UHRF2
      Background InformationUHRF2 plays a critical role in cell cycle as it ubiquitinates cyclins and induces G1 arrest. UHRF2 also participates in epigenetic control of gene expression in many cells through binding and ubiquitinating DNA and histone binding proteins and targeting them for degradation. UHRF2 binds methylated CpG containing oligonucleotides as well and interacts directly with histone H3 as well as the trimethylated form of H3. UHRF2 is also recruited to areas of DNA damage and is important for DNA stability. UHRF2 is localized in the nucleus in heterochromatin. UHRF2 up regulated expression is associated with various cancers, however typically as mutated or lower copy number forms, which appear to has impaired anti-proliferation abilities.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-E3 ubiquitin-protein ligase UHRF2 Antibody is an antibody against E3 ubiquitin-protein ligase UHRF2 for use in Immunohistochemistry and Immunocytochemistry.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected E3 ubiquitin-protein ligase UHRF2 in human testis and human kidney tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the region required for interaction with histone H3 and interaction with PCNP of human E3 ubiquitin-protein ligase UHRF2.
      EpitopeRegion required for interaction with histone H3 and interaction with PCNP
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • UHRF2
      • NIRF
      • RNF107
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~58 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in WI-38 cell lysate.

      Western Blotting Analysis: A 1:5,000 dilution of this antibody detected E3 ubiquitin-protein ligase UHRF2 in 10 µg of WI-38 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE1028 04055977135220