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MABC602 Anti-Ferritin Heavy Chain Antibody, clone 1-2.3.1.2

This Anti-Ferritin Heavy Chain Antibody, clone 1-2.3.1.2 is validated for use in Western Blotting and Immunohistochemistry for the detection of Ferritin Heavy Chain.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: FTH1, FTH, FTHL6 UniProt Number: P02794
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MABC602
100 µg  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC602
      DescriptionAnti-Ferritin Heavy Chain Antibody, clone 1-2.3.1.2
      Alternate Names
      • Ferritin heavy chain
      • Ferritin H subunit
      • Cell proliferation-inducing gene 15 protein
      • Ferritin heavy chain, N-terminally processed
      Background InformationFerritin is a widely expressed, very large, multi-subunit, intracellular protein that stores iron and releases it in a controlled fashion. The protein is produced by almost all living organisms in some form. In humans, it acts as a buffer against iron deficiency and iron overload. Ferritin protein is a multi-subunit (24 oligomers) protein complex consisting of both large (heavy) and small (light) chains. It is primarily and intracellular protein.The subunits of Ferritin in vertebrates have an apparent molecular weight of 19 kDa or 21 kDa respectively; their sequences are about 50% homologous. When Ferritin is unbound by iron the protein is called Apoferritin. Mutations associated with the Ferritin Heavy Chain protein contribute to a syndrome called Hemochromatosis 5 which is a disorder of iron metabolism where too much iron is retained within the tissues resulting in a variety of syndromes which unfortunately manifest themselves late in life.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Ferritin Heavy Chain Antibody, clone 1-2.3.1.2 is validated for use in Western Blotting and Immunohistochemistry for the detection of Ferritin Heavy Chain.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Ferritin Heavy Chain in human bone marrow and human tonsil tissue.
      Immunohistochemistry Analysis: A representative lot detected Ferritin Heavy Chain in erythroid blasts of acute myeloid leukaemia M6 tissue, macrophages in the lymph node tissue, and tumor & lung-associated macrophages (Wang, W., et al. (2013). Histopahtology. 62:931–940).
      Biological Information
      ImmunogenRecombinant protein corresponding to human Ferritin Heavy Chain.
      Clone1-2.3.1.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FTH1
      • FTH
      • FTHL6
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~21 kDa observed. Uncharacterized band may be observed at ~200 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in U251 cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected Ferritin Heavy Chain in 10 µg of U251 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC602 04053252986505

      Documentation

      Anti-Ferritin Heavy Chain Antibody, clone 1-2.3.1.2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Ferritin Heavy Chain Antibody, clone 1-2.3.1.2 Certificates of Analysis

      TitleLot Number
      Anti-Ferritin Heavy Chain, clone 1-2.3.1.2 - Q2447815 Q2447815
      Anti-Ferritin Heavy Chain, clone 1-2.3.1.2 - 3734487 3734487
      Anti-Ferritin Heavy Chain, clone 1-2.3.1.2 - 3988957 3988957
      Anti-Ferritin Heavy Chain, clone 1-2.3.1.2 - 4059290 4059290
      Anti-Ferritin Heavy Chain, clone 1-2.3.1.2 Monoclonal Antibody 3134102
      Anti-Ferritin Heavy Chain, clone 1-2.3.1.2 Monoclonal Antibody 3003758

      References

      Reference overviewPub Med ID
      Ferritin H is a novel marker of early erythroid precursors and macrophages.
      Wang, Wei, et al.
      Histopathology, 62: 931-40 (2013)  2013

      Show Abstract       		23611361 23611361