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ABC955 Anti-GADD153/DDIT3/CHOP Antibody

This Anti-GADD153/DDIT3/CHOP antibody is validated for use in Western Blotting for the detection of GADD153/DDIT3/CHOP.

Anti-GADD153/DDIT3/CHOP Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: DDIT3, CHOP, CHOP10, GADD153 UniProt Number: P35638
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ABC955
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC955
      DescriptionAnti-GADD153/DDIT3/CHOP Antibody
      Alternate Names
      • DNA damage-inducible transcript 3 protein
      • DDIT-3
      • C/EBP zeta
      • C/EBP-homologous protein
      • CHOP
      • C/EBP-homologous protein 10
      • CHOP-10
      • CCAAT/enhancer-binding protein homologous protein
      • Growth arrest and DNA damage-inducible protein GADD153
      • GADD153/DDIT3/CHOP
      Background InformationDNA damage-inducible transcript 3 protein (UniProt P35638; also known as CCAAT/enhancer-binding protein homologous protein, C/EBP-homologous protein 10, C/EBP zeta, CHOP, CHOP-10, DDIT-3, Growth arrest and DNA damage-inducible protein GADD153) is encoded by the DDIT3 (also known as CEBPZ, CHOP, CHOP10, GADD153) gene in human (Gene ID 1649). CHOP is a proapoptotic unfold protein response (UPR) gene and a well established marker for ER stress and UPR activation. The accumulation of unfolded or misfolded proteins in the ER induces the activation of three main UPR pathways, the inositol requiring enzyme-1 (IRE1) pathway, the activating transcription factor 6 (ATF6) pathway, and the protein kinase-like ER kinase (PERK) pathway. The PERK pathway involves PERK auto-phosphorylation/activation, resulting in PERK phosphorylation of eIF2α, which in turn leads to increased ATF4 transcription and ATF4-mediated CHOP upregulation.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-GADD153/DDIT3/CHOP antibody is validated for use in Western Blotting for the detection of GADD153/DDIT3/CHOP.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human GADD153/DDIT3/CHOP near the N-terminus.
      EpitopeNear N-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Bovine, Mouse, Rat, Monkey, Porcine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • DDIT3
      • CHOP
      • CHOP10
      • GADD153
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~29 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Tunicamycin treated HeLa cell lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected GADD153/DDIT3/CHOP in 10 µg of Tunicamycin treated HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC955 04055977116991

      Documentation

      Anti-GADD153/DDIT3/CHOP Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-GADD153/DDIT3/CHOP Antibody Certificates of Analysis

      TitleLot Number
      Anti-GADD153/DDIT3/CHOP Q2485583
      Anti-GADD153/DDIT3/CHOP - 3188636 3188636
      Anti-GADD153/DDIT3/CHOP - 3324192 3324192
      Anti-GADD153/DDIT3/CHOP - 3749979 3749979
      Anti-GADD153/DDIT3/CHOP - 3919640 3919640
      Anti-GADD153/DDIT3/CHOP - 4125697 4125697
      Anti-GADD153/DDIT3/CHOP -2730018 2730018
      Anti-GADD153/DDIT3/CHOP -2789067 2789067
      Anti-GADD153/DDIT3/CHOP Polyclonal Antibody 2937367
      Anti-GADD153/DDIT3/CHOP Polyclonal Antibody 2953852

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies